Changed cyclic guanosine monophosphate atrial natriuretic factor relationship in hypertensive man

Niels Eske Bruun, Meta Damkjaer Nielsen, Peter Sk Ø Tt, Jørn Giese, Arne Leth, Hans Jørgen Schütten, Sten Rasmussen

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    Abstrakt

    Plasma concentrations of atrial natriuretic factor (ANF) and cyclic guanosine monophosphate (cGMP) were measured in 10 patients with essential hypertension and 10 normoten-sive controls on the fifth day of a low (50 mmol/day), a medium (180 mmol/day) and a high (380 mmol/day) dietary sodium intake. Plasma ANF and cGMP concentrations were less on the low than on the high sodium intake. Values for ANF on the medium sodium intake were intermediate. In normotensive subjects cGMP concentrations did not differ significantly on the low and the medium sodium intake. As compared with the controls plasma concentrations of cGMP were significantly increased in hypertensive patients on all three levels of sodium intake, while ANF concentrations were identical in the two groups. Since cGMP is a second messenger to ANF the data suggest an increased cellular response to ANF in patients with essential hypertension.

    OriginalsprogEngelsk
    Sider (fra-til)287-291
    Antal sider5
    TidsskriftJournal of Hypertension
    Vol/bind7
    Udgave nummer4
    StatusUdgivet - apr. 1989

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