Change in mammographic density across birth cohorts of Dutch breast cancer screening participants

George Napolitano*, Elsebeth Lynge, Martin Lillholm, Ilse Vejborg, Carla H van Gils, Mads Nielsen, Nico Karssemeijer

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


High mammographic density is a well-known risk factor for breast cancer. This study aimed to search for a possible birth cohort effect on mammographic density, which might contribute to explain the increasing breast cancer incidence. We separately analyzed left and right breast density of Dutch women from a 13-year period (2003-2016) in the breast cancer screening programme. First, we analyzed age-specific changes in average percent dense volume (PDV) across birth cohorts. A linear regression analysis (PDV vs. year of birth) indicated a small but statistically significant increase in women of: 1) age 50 and born from 1952 to 1966 (left, slope?= 0.04, p = 0.003; right, slope?= 0.09, p < 0.0001); 2) age 55 and born from 1948 to 1961 (right, slope?= 0.04, p = 0.01); and 3) age 70 and born from 1933 to 1946 (right, slope?= 0.05, p = 0.002). A decrease of total breast volume seemed to explain the increase in PDV. Second, we compared proportion of women with dense breast in women born in 1946-1953 and 1959-1966, and observed a statistical significant increase of proportion of highly dense breast in later born women, in the 51 to 55 age-groups for the left breast (around a 20% increase in each age-group), and in the 50 to 56 age-groups for the right breast (increase ranging from 27% to 48%). The study indicated a slight increase in mammography density across birth cohorts, most pronounced for women in their early 50s, and more marked for the right than for the left breast.

Sider (fra-til)2954-2962
Antal sider9
TidsskriftInternational Journal of Cancer
Udgave nummer11
StatusUdgivet - 1 dec. 2019

Bibliografisk note

� 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.


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