TY - JOUR
T1 - Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes
AU - Winckler, Karoline
AU - Wiinberg, Niels
AU - Jensen, Andreas Kryger
AU - Thorsteinsson, Birger
AU - Lundby-Christensen, Louise
AU - Heitmann, Berit Lilienthal
AU - Jensen, Gorm Boje
AU - Tarnow, Lise
PY - 2018/8/18
Y1 - 2018/8/18
N2 - Carotid intima-media thickness (IMT) and ankle brachial index (ABI) are non-invasive indicators of generalised atherosclerosis. The aim was to determine the association between carotid IMT and ABI in subjects with and without diabetes mellitus (DM), and to analyse specific age change-points. We included 2744 subjects from the Copenhagen City Heart Study (mean age (SD) 56.6 (17.2) years, 56.8% women and body mass index (BMI) 25.4 (4.1) kg/m 2 ). Carotid IMT and ABI measurements were performed during the fifth examination. Of the 2744 subjects, 125 subjects (4.6%) had DM. Average carotid IMT was 0.667 (0.145) mm and ABI was 1.06 (0.14). Subjects with DM were older, had higher BMI and systolic blood pressure (SBP) (all p <.001). Carotid IMT was higher in subjects with DM (0.754 (0.150) mm) compared to subjects without DM (0.662 (0.144) mm) (p <.001), whereas there was no difference in ABI between the two groups. ABI was inversely associated with carotid IMT (slope = −0.17 [−0.207; −0.137] (p <.001). The association remained significant after adjustment for risk factors both in subjects with DM (slope = −0.168 [−0.328; −0.007], p =.040), and in subjects without DM (slope = −0.100 [−0.148; −0.052], p <.001), with a stronger effect of carotid IMT on ABI among subjects with DM. Carotid IMT and ABI were inversely associated in subjects with DM and without DM, but with a stronger effect in subjects with DM. Age and ABI revealed a change-point with a stronger inverse association among subjects aged >60 years.
AB - Carotid intima-media thickness (IMT) and ankle brachial index (ABI) are non-invasive indicators of generalised atherosclerosis. The aim was to determine the association between carotid IMT and ABI in subjects with and without diabetes mellitus (DM), and to analyse specific age change-points. We included 2744 subjects from the Copenhagen City Heart Study (mean age (SD) 56.6 (17.2) years, 56.8% women and body mass index (BMI) 25.4 (4.1) kg/m 2 ). Carotid IMT and ABI measurements were performed during the fifth examination. Of the 2744 subjects, 125 subjects (4.6%) had DM. Average carotid IMT was 0.667 (0.145) mm and ABI was 1.06 (0.14). Subjects with DM were older, had higher BMI and systolic blood pressure (SBP) (all p <.001). Carotid IMT was higher in subjects with DM (0.754 (0.150) mm) compared to subjects without DM (0.662 (0.144) mm) (p <.001), whereas there was no difference in ABI between the two groups. ABI was inversely associated with carotid IMT (slope = −0.17 [−0.207; −0.137] (p <.001). The association remained significant after adjustment for risk factors both in subjects with DM (slope = −0.168 [−0.328; −0.007], p =.040), and in subjects without DM (slope = −0.100 [−0.148; −0.052], p <.001), with a stronger effect of carotid IMT on ABI among subjects with DM. Carotid IMT and ABI were inversely associated in subjects with DM and without DM, but with a stronger effect in subjects with DM. Age and ABI revealed a change-point with a stronger inverse association among subjects aged >60 years.
KW - Ageing
KW - ankle brachial index
KW - cardiovascular disease
KW - carotid intima-media thickness
KW - diabetes mellitus
KW - peripheral artery disease
UR - http://www.scopus.com/inward/record.url?scp=85052076794&partnerID=8YFLogxK
U2 - 10.1080/00365513.2018.1499124
DO - 10.1080/00365513.2018.1499124
M3 - Article
C2 - 30073874
AN - SCOPUS:85052076794
SN - 0036-5513
VL - 78
SP - 464
EP - 469
JO - Scandinavian Journal of Clinical and Laboratory Investigation
JF - Scandinavian Journal of Clinical and Laboratory Investigation
IS - 6
ER -