Cardiovascular Risk Factors in Type I (Insulin‐dependent) Diabetic Patients with and without Proteinuria

FLEMMING VALDORF‐HANSEN, TONNY JENSEN*, KNUT BORCH‐JOHNSEN, TORSTEN DECKERT

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    ABSTRACT. In diabetes mellitus cardiovascular mortality among patients with increased urinary albumin excretion seems to be higher than in patients with normal urinary albumin excretion. Therefore we investigated blood pressure, total cholesterol, fibrinogen and in vivo platelet adhesion in 61 patients with type I (insulin‐dependent) diabetes, 39 without complications, such as retinopathy or proteinuria and 22 with proteinuria and slightly elevated serum creatinine. The two groups had similar age, sex, diabetes duration and glucose control. Blood pressure, total cholesterol, fibrinogen and in vivo platelet adhesion were all significantly elevated in patients with proteinuria (p<0.01), whereas these parameters were normal in the uncomplicated diabetic patients, independent of diabetes duration. The mortality of cardiovascular disease during 20 years' follow‐up was significantly higher among patients with proteinuria compared with patients without proteinuria (p<0.001), indicating that these risk factors contribute to the increased cardiovascular mortality in patients with clinical nephropathy. 1987 Association for the Publication of the Journal of Internal Medicine

    OriginalsprogEngelsk
    Sider (fra-til)439-444
    Antal sider6
    TidsskriftActa Medica Scandinavica
    Vol/bind222
    Udgave nummer5
    DOI
    StatusUdgivet - 1 jan. 1987

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