Cardiac arrest in anti-mitochondrial antibody associated inflammatory myopathy

Pil Højgaard, Nanna Witting, Kasper Rossing, Redi Pecini, Thomas Hartvig Lindkær Jensen, Philip Hasbak, Louise P Diederichsen

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Abstrakt

Insight into predictors of cardiac involvement in inflammatory myopathies is sparse. A negative prognostic role of anti-mitochondrial antibodies (AMA) has been noticed and is supported by the current case. We describe a male patient who at the age 40 suffered a cardiac arrest and over the following months experienced progressive heart failure, arrhythmias and proximal muscle weakness. Clinical, genetic and serologic testing and repeated imaging- and histopathological investigations resulted in a diagnosis of AMA-associated, necrotizing, inflammatory myositis with cardiac involvement. Besides a cardiac resynchronization therapy defibrillator, heart failure and antiarrhythmic drugs the patient received successive immunosuppressants, which improved skeletal muscle strength but not cardiac disease progression. At age 45 he died from end-stage heart failure. Clinicians must be aware of AMA-associated myositis as a cause of unclarified heart disease, even in patients with initially sparse extra-cardiac manifestations. Further knowledge of treatment strategies is highly needed for this disease entity.

OriginalsprogEngelsk
Artikelnummeromaa150
TidsskriftOxford Medical Case Reports
Vol/bind2021
Udgave nummer3
DOI
StatusUdgivet - mar. 2021

Bibliografisk note

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