Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura

H. W. Schytz, T. Wienecke, J. Olesen, M. Ashina

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Carbachol induces headache in healthy subjects, but the migraine eliciting effect of carbachol has not previously been studied. We hypothesized that the cholinomimetic agonist carbachol would induce headache and migraine-like attacks in migraineurs. Carbachol (3 μg/kg) or placebo was randomly infused into 18 patients with migraine without aura in a double-blind crossover study. Headache was scored on a verbal rating scale from 0 to 10. Velocity in the middle cerebral artery (VMCA) and diameter of the superficial temporal artery (STA) were recorded. Fifteen patients experienced headache after carbachol compared with eight after placebo (P = 0.039). There was no difference in incidence of migraine-like attacks after carbachol (n = 8) compared with placebo (n = 6) (P = 0.687). Carbachol caused a decrease in VMCA (P = 0.044), but no change in STA (P = 0.089) compared with placebo. The study demonstrated that carbachol provocation is not a good model for experimental migraine.

OriginalsprogEngelsk
Sider (fra-til)337-345
Antal sider9
TidsskriftCephalalgia
Vol/bind30
Udgave nummer3
DOI
StatusUdgivet - 1 mar. 2010
Udgivet eksterntJa

Fingeraftryk

Udforsk hvilke forskningsemner 'Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura' indeholder.

Citationsformater