Cancer incidence and mortality in women occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins

Manolis Kogevinas, Rodolfo Saracci, Regina Winkelmann, Eric S. Johnson, Pier Alberto Bertazzi, Bas H. Bueno de Mesquita, Timo Kauppinen, Margareta Littorin, Elsebeth Lynge, Manfred Neuberger, Neil Pearce

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    The association between exposure to chlorophenoxy herbicides contaminated with dioxins and occurrence of cancer has been studied mainly in male populations. In animal experiments, gender differences have been recorded in the cancer response to administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mortality and cancer incidence in an international cohort of 701 women from an International Register of Workers occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins is examined. Cause-specific, national death rates and cancer incidence rates were used as referents. Cancer risk was not increased overall, with a standardized incidence ratio (SIR) of 96 and 95 percent confidence interval (CI) of 64-137, based on 29 cases. Among workers exposed to those chlorophenoxy herbicides contaminated with TCDD, excess cancer incidence (for all sites) was observed (SIR=222, CI=102-422, 9 cases); this was highest in the first 10 years after exposure. No excess was observed for breast cancer, the most common cancer in this cohort. Results on cancer mortality were consistent with those on incidence.

    OriginalsprogEngelsk
    Sider (fra-til)547-553
    Antal sider7
    TidsskriftCancer Causes and Control
    Vol/bind4
    Udgave nummer6
    DOI
    StatusUdgivet - 1 nov. 1993

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Cancer incidence and mortality in women occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins' indeholder.

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