Brief rapport: Perceptual aberration in patients at ultra-high risk for psychosis

Lars Clemmensen*, Tina Dam Kristensen, Christina Wenneberg, Martin Køster Rimvall, Merete Nordentoft, Louise Glenthoej

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: Ultra-high risk (UHR) is considered a forerunner of psychosis, but most UHR individuals do not later convert, yet remain symptomatic, disabled and help-seeking. Thus, there is an increased recognition of the UHR phenotype as a syndrome in itself, rather than merely a risk syndrome. It is therefore essential to investigate outcomes other than transition to psychosis. For this purpose, perceptual aberration appears to be a distinct, as well as a stable and less state-specific vulnerability indicator. We aimed to investigate perceptual aberration and associations with functional, neuro and social cognitive risk factors in an UHR sample.

METHOD: One hundred and twenty UHR and 64 healthy controls were compared on levels of perceptual aberration using the perceptual aberration scale. We further investigated cross-sectional associations between perceptual aberration and CAARMS (as a measure of subthreshold psychotic symptoms) and functional, neuro and social cognitive risk factors within the UHR using Spearmans ρ.

RESULTS: Perceptual aberration was significantly higher in UHR than in healthy controls and was associated with social functioning, executive functioning, and emotion recognition.

CONCLUSION: Our findings are consistent with a view of perceptual aberration as a stable vulnerability indicator that varies little with clinical state.

Sider (fra-til)63-68
Antal sider6
TidsskriftEarly intervention in psychiatry
Udgave nummer1
Tidlig onlinedato31 maj 2023
StatusUdgivet - jan. 2024

Bibliografisk note

© 2023 The Authors. Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd.


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