Breast cancer after bilateral risk-reducing mastectomy

A. B. Skytte*, D. Crüger, M. Gerster, A. V. Lænkholm, C. Lang, K. Brøndum-Nielsen, Mk Andersen, L. Sunde, S. Kølvraa, A. M. Gerdes

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

    Sider (fra-til)431-437
    Antal sider7
    TidsskriftClinical Genetics
    Udgave nummer5
    StatusUdgivet - 1 maj 2011


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