Biochemical evaluation of endometrial function at the time of implantation

Anette Lindhard, Ursula Bentin-Ley, Vibeke Ravn, Henrik Islin, Thomas Hviid, Sven Rex, Susanne Bangsboll, Steen Sorensen

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    Objective: To review the literature on various endometrial factors assumed to be of importance to implantation and to evaluate their potential clinical value in the assessment of endometrial function at the time of implantation in infertile women in natural and stimulated cycles. Design: Literature review. Result(s): Cytokines such as leukemia inhibitory factor, colony-stimulating factor-1, and interleukin-1 have all been shown to play important roles in the cascade of events that leads to implantation. They participate in a synchronized cooperation between the endometrium and the preimplanting embryo under the influence of steroid hormones. The same applies to the integrin αvβ3, glycodelin, and the polymorphic mucin 1. The usefulness of these factors to assess endometrial receptivity and to estimate the prognosis for pregnancy in natural and artificial cycles remains to be proven. Conclusion(s): The studies performed to date have mostly included only small groups of patients with a lack of fertile controls, and only a few prospective, controlled trials have been carried out. Therefore, definite conclusions about the clinical value of these factors in the assessment of endometrial function and prognosis for pregnancy after artificial reproductive therapy cannot be drawn at present. Further evaluation of their importance for and function during implantation is needed.

    OriginalsprogEngelsk
    Sider (fra-til)221-233
    Antal sider13
    TidsskriftFertility and Sterility
    Vol/bind78
    Udgave nummer2
    DOI
    StatusUdgivet - 12 aug. 2002

    Fingeraftryk Udforsk hvilke forskningsemner 'Biochemical evaluation of endometrial function at the time of implantation' indeholder.

    Citationsformater