Abstract
The aim of the study was to evaluate the effect of an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene on progression of diabetic nephropathy. We performed an observational follow-up study of 35 patients with insulin-dependent diabetes and diabetic nephropathy. Patients were investigated during captopril treatment for a median of seven (range three to nine) years. Eleven patients were homozygous for the deletion allele (DD) and 24 were hetero- or homozygous for the insertion allele (ID+II). The two groups had comparable glomerular filtration rate, albuminuria and blood pressure at baseline and captopril induced nearly the same mean reduction in blood pressure - to 103 (SD 5) mm Hg in the DD-group and 102 (8) mm Hg in the ID+II-group. The rate of decline in glomerular filtration rate was significantly steeper in the DD group than in the other group (mean 5.7 (SD 3.7) versus 2.6 (2.8) ml/min/year, p = 0.01). In conclusion, the deletion polymorphism in the ACE gene reduces the long term beneficial effect of ACE inhibition on the progression of diabetic nephropathy in patients with insulin dependent diabetes.
Bidragets oversatte titel | Deletion polymorphism in the angiotensin converting enzyme (ACE) gene: Significance for progression of ACE-inhibition treated diabetic nephropathy |
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Originalsprog | Dansk |
Sider (fra-til) | 4886-4889 |
Antal sider | 4 |
Tidsskrift | Ugeskrift for laeger |
Vol/bind | 160 |
Udgave nummer | 34 |
Status | Udgivet - 17 aug. 1998 |