Baseline findings of the population-based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65-74 years

J S Lindholt, L M Rasmussen, R Søgaard, J Lambrechtsen, F H Steffensen, L Frost, K Egstrup, G Urbonaviciene, M Busk, M H Olsen, J Hallas, A C Diederichsen

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Abstrakt

BACKGROUND: The challenge of managing age-related diseases is increasing; routine checks by the general practitioner do not reduce cardiovascular mortality. The aim here was to reduce cardiovascular mortality by advanced population-based cardiovascular screening. The present article reports the organization of the study, the acceptability of the screening offer, and the relevance of multifaceted screening for prevention and management of cardiovascular disease.

METHODS: Danish men aged 65-74?years were invited randomly (1?:?2) to a cardiovascular screening examination using low-dose non-contrast CT, ankle and brachial BP measurements, and blood tests.

RESULTS: In all, 16 768 of 47?322 men aged 65-74?years were invited and 10 471 attended (uptake 62�4 per cent). Of these, 3481 (33�2 per cent) had a coronary artery calcium score above 400?units. Thoracic aortic aneurysm was diagnosed in the ascending aorta (diameter 45?mm or greater) in 468 men (4�5 per cent), in the arch (at least 40?mm) in 48 (0�5 per cent) and in the descending aorta (35?mm or more) in 233 (2�2 per cent). Abdominal aortic aneurysm (at least 30?mm) and iliac aneurysm (20?mm or greater) were diagnosed in 533 (5�1 per cent) and 239 (2�3 per cent) men respectively. Peripheral artery disease was diagnosed in 1147 men (11�0 per cent), potentially uncontrolled hypertension (at least 160/100?mmHg) in 835 (8�0 per cent), previously unknown atrial fibrillation confirmed by ECG in 50 (0�5 per cent), previously unknown diabetes mellitus in 180 (1�7 per cent) and isolated severe hyperlipidaemia in 48 men (0�5 per cent). In all, 4387 men (41�9 per cent), excluding those with potentially uncontrolled hypertension, were referred for additional cardiovascular prevention. Of these, 3712 (35�5 per cent of all screened men, but 84�6 per cent of those referred) consented and were started on medication.

CONCLUSION: Multifaceted cardiovascular screening is feasible and may optimize cardiovascular disease prevention in men aged 65-74?years. Uptake is lower than in aortic aneurysm screening.

OriginalsprogEngelsk
Sider (fra-til)862-871
Antal sider10
TidsskriftBritish Journal of Surgery
Vol/bind106
Udgave nummer7
DOI
StatusUdgivet - jun. 2019

Bibliografisk note

� 2019 BJS Society Ltd Published by John Wiley & Sons Ltd.

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Udforsk hvilke forskningsemner 'Baseline findings of the population-based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65-74 years' indeholder.

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