TY - JOUR
T1 - Bacteremia with the bovis group streptococci
T2 - Species identification and association with infective endocarditis and with gastrointestinal disease
AU - Marmolin, Ea S.
AU - Hartmeyer, Gitte N.
AU - Christensen, Jens J.
AU - Nielsen, Xiaohui C.
AU - Dargis, Rimtas
AU - Skov, Marianne N.
AU - Knudsen, Elisa
AU - Kemp, Michael
AU - Justesen, Ulrik S.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.
AB - DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.
KW - Bacteremia
KW - Bovis group streptococci
KW - Colorectal cancer
KW - Infective endocarditis
KW - Sequencing of the intergenic spacer region
UR - http://www.scopus.com/inward/record.url?scp=84964403158&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2016.02.019
DO - 10.1016/j.diagmicrobio.2016.02.019
M3 - Article
C2 - 27117515
AN - SCOPUS:84964403158
SN - 0732-8893
VL - 85
SP - 239
EP - 242
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
ER -