Autoimmune diseases in microscopic colitis: A Danish nationwide case-control study

Signe Wildt*, Lars Kristian Munck, Matilde Winther-Jensen, Tine Jess, Nynne Nyboe Andersen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: The association between autoimmune diseases and microscopic colitis remains uncertain.

AIMS: To describe the association between autoimmune diseases and microscopic colitis by using a matched case-control design based on nationwide registry data.

METHODS: All adult Danish patients with a diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries. Odds of autoimmune diseases were compared between cases with microscopic colitis and sex- and age-matched controls from the background population in a 1:10 ratio and evaluated by logistic regression calculating odds ratios (OR) with 95% confidence intervals (CI) adjusted for comorbidity. Analyses were stratified according to sex, age and the subtypes of lymphocytic and collagenous colitis.

RESULTS: We identified 15 597 cases with microscopic colitis and matched to 155 910 controls. In total, 3491 (22%) of patients with microscopic colitis had concomitant autoimmune disease compared to 16 521 (11%) of controls (OR, 2.46; 95% CI, 2.36-2.56). Adjusting for comorbidities reduced the OR to 2.09 (95% CI, 2.01-2.19). Analyses showed increased ORs with 16 different autoimmune diseases, particularly of gastrointestinal and endocrine origin, and connective tissue disorders. The highest ORs were for coeliac disease (OR = 10.15; 95% CI, 8.20-12.6), Crohn's disease (OR = 2.47; 95% CI, 2.10-2.91) and ulcerative colitis (OR = 6.73; 95% CI, 6.20-7.30). In stratified analyses younger age at diagnosis and collagenous colitis were associated with higher odds.

CONCLUSION: Using nationwide registry data, microscopic colitis was associated with a wide range of autoimmune diseases, especially of gastrointestinal origin. The results suggest an autoimmune predisposition to microscopic colitis.

Sider (fra-til)1454-1462
Antal sider9
TidsskriftAlimentary Pharmacology and Therapeutics
Udgave nummer11-12
Tidlig onlinedato15 okt. 2021
StatusUdgivet - dec. 2021

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© 2021 John Wiley & Sons Ltd.


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