Atopic diseases by filaggrin mutations and birth year

Jacob Pontoppidan Thyssen, A. Linneberg, J. D. Johansen, B. C. Carlsen, C. Zachariae, M. Meldgaard, P. B. Szecsi, S. Stender, T. Menné

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Background: The prevalence of atopic disorders has increased in recent years. The pathogenesis is complex with genetic and environmental risk factors. Filaggrin loss-of-function mutations are common and associated with atopic disorders. We investigated whether the prevalence of filaggrin mutations increased in different birth cohorts in adults from the general population in Denmark. Methods: Cross-sectional questionnaire and filaggrin gene mutation (R501X and 2282del4) data from 3335 18- to 69-year-old adults were available for analyses. Results: The effect of filaggrin mutations on the prevalence of atopic diseases, albeit not statistically significant, depended mostly on birth year for atopic dermatitis (AD). A nonsignificant increase in the prevalence of filaggrin mutations was noted across birth year groups reporting AD, with 12.9% in adults born in 1936-1949 and 19.0% born in 1976-1988. Conclusions: If confirmed in other populations, the observed increase suggests that mutation carriers have been more susceptible to environmental changes accentuating the rise in AD prevalence.

    OriginalsprogEngelsk
    Sider (fra-til)705-708
    Antal sider4
    TidsskriftAllergy: European Journal of Allergy and Clinical Immunology
    Vol/bind67
    Udgave nummer5
    DOI
    StatusUdgivet - 1 maj 2012

    Fingeraftryk Udforsk hvilke forskningsemner 'Atopic diseases by filaggrin mutations and birth year' indeholder.

    Citationsformater