Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers

Torben Steiniche; Morten Ladekarl; Jeanette Bæhr Georgsen; Simon Andreasen; Michael Busch-Sørensen; Wei Zhou; Matthew J Marton; Scott K Pruitt; Fan Jin; Kai-Li Liaw

doi:10.2144/fsoa-2020-0063

Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers

Torben Steiniche^*
, Morten Ladekarl
, Jeanette Bæhr Georgsen
, Simon Andreasen
, Michael Busch-Sørensen
, Wei Zhou
, Matthew J Marton
, Scott K Pruitt
, Fan Jin
, Kai-Li Liaw

^*Corresponding author af dette arbejde

Øre-, Næse- og Halskirurgisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Aim: PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value are unknown in many cancers.

Methods: We retrospectively evaluated PD-L1 combined positive score (CPS) and MSI-H and their association with clinical outcomes among patients with ten advanced uncommon cancers.

Results: 398 of 426 patients (93%) had a valid PD-L1 result; most (242; 61%) had CPS ≥1. Prevalence of MSI-H tumors was 8/360. Median overall survival was shorter among patients with PD-L1 CPS ≥1 tumors after first-line treatment (23.0 vs 39.7 months, p = 0.014).

Conclusion: PD-L1 was commonly expressed in solid tumors, and CPS ≥1 was associated with shorter overall survival. Prevalence of MSI-H was low.

Originalsprog	Engelsk
Artikelnummer	FSO616
Tidsskrift	Future Science OA
Vol/bind	6
Udgave nummer	8
DOI	https://doi.org/10.2144/fsoa-2020-0063
Status	Udgivet - 19 aug. 2020

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10.2144/fsoa-2020-0063Licens: CC BY

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@article{cb1838dc6609459d889755542cc5f4d6,

title = "Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers",

abstract = "Aim: PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value are unknown in many cancers.Methods: We retrospectively evaluated PD-L1 combined positive score (CPS) and MSI-H and their association with clinical outcomes among patients with ten advanced uncommon cancers.Results: 398 of 426 patients (93\%) had a valid PD-L1 result; most (242; 61\%) had CPS ≥1. Prevalence of MSI-H tumors was 8/360. Median overall survival was shorter among patients with PD-L1 CPS ≥1 tumors after first-line treatment (23.0 vs 39.7 months, p = 0.014).Conclusion: PD-L1 was commonly expressed in solid tumors, and CPS ≥1 was associated with shorter overall survival. Prevalence of MSI-H was low.",

keywords = "anal carcinoma, biliary adenocarcinoma, cervical carcinoma, endometrial carcinoma, mesothelioma, neuroendocrine tumors, salivary gland carcinoma, small-cell lung carcinoma, thyroid carcinoma, vulvar carcinoma",

author = "Torben Steiniche and Morten Ladekarl and Georgsen, \{Jeanette B{\ae}hr\} and Simon Andreasen and Michael Busch-S{\o}rensen and Wei Zhou and Marton, \{Matthew J\} and Pruitt, \{Scott K\} and Fan Jin and Kai-Li Liaw",

note = "{\textcopyright} 2020 Merck Sharp \& Dohme Corp., a subsidiary of Merck \& Co., Inc., Kenilworth, NJ, USA.",

year = "2020",

month = aug,

day = "19",

doi = "10.2144/fsoa-2020-0063",

language = "English",

volume = "6",

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TY - JOUR

T1 - Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers

AU - Steiniche, Torben

AU - Ladekarl, Morten

AU - Georgsen, Jeanette Bæhr

AU - Andreasen, Simon

AU - Busch-Sørensen, Michael

AU - Zhou, Wei

AU - Marton, Matthew J

AU - Pruitt, Scott K

AU - Jin, Fan

AU - Liaw, Kai-Li

PY - 2020/8/19

Y1 - 2020/8/19

N2 - Aim: PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value are unknown in many cancers.Methods: We retrospectively evaluated PD-L1 combined positive score (CPS) and MSI-H and their association with clinical outcomes among patients with ten advanced uncommon cancers.Results: 398 of 426 patients (93%) had a valid PD-L1 result; most (242; 61%) had CPS ≥1. Prevalence of MSI-H tumors was 8/360. Median overall survival was shorter among patients with PD-L1 CPS ≥1 tumors after first-line treatment (23.0 vs 39.7 months, p = 0.014).Conclusion: PD-L1 was commonly expressed in solid tumors, and CPS ≥1 was associated with shorter overall survival. Prevalence of MSI-H was low.

AB - Aim: PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value are unknown in many cancers.Methods: We retrospectively evaluated PD-L1 combined positive score (CPS) and MSI-H and their association with clinical outcomes among patients with ten advanced uncommon cancers.Results: 398 of 426 patients (93%) had a valid PD-L1 result; most (242; 61%) had CPS ≥1. Prevalence of MSI-H tumors was 8/360. Median overall survival was shorter among patients with PD-L1 CPS ≥1 tumors after first-line treatment (23.0 vs 39.7 months, p = 0.014).Conclusion: PD-L1 was commonly expressed in solid tumors, and CPS ≥1 was associated with shorter overall survival. Prevalence of MSI-H was low.

KW - anal carcinoma

KW - biliary adenocarcinoma

KW - cervical carcinoma

KW - endometrial carcinoma

KW - mesothelioma

KW - neuroendocrine tumors

KW - salivary gland carcinoma

KW - small-cell lung carcinoma

KW - thyroid carcinoma

KW - vulvar carcinoma

U2 - 10.2144/fsoa-2020-0063

DO - 10.2144/fsoa-2020-0063

M3 - Article

C2 - 32983568

SN - 2056-5623

VL - 6

JO - Future Science OA

JF - Future Science OA

IS - 8

M1 - FSO616

ER -

Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers

Abstract

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