Association of body mass index, blood pressure and serum levels of triglycerides and high-density lipoprotein cholesterol in childhood with the insulin sensitivity index in young adulthood: A 13-year follow-up

Jesper O. Clausen*, Hans Ibsen, Karsten K. Ibsen, Knut Borch-Johnsen

*Corresponding author af dette arbejde

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    Abstract

    Background Tracking of body mass index (BMI), blood pressure and serum lipids from childhood to adulthood has been demonstrated in previous studies. Whether these factors are associated with the insulin-sensitivity index measured in young adulthood (ISI>adult) remains undetermined. Objectives To determine whether any association exists between the ISI>adult and BMI, blood pressure and plasma lipids measured in childhood (1979). Methods The study included 227 unrelated white subjects (aged 18–32 years). Their ISI>adult were measured in 1992/93, with a combined intravenous glucose (0.3 gl/kg body weight) and tolbutamide (3 mg/kg body weight) tolerance test. BMI, blood pressure and blood lipids were measured in 1979 and again in 1992/93. Results In men, plasma high-density lipoprotein cholesterol (HDLC) in 1979 (r>s = 0.25, P = 0.006) was positively associated with ISI>adult and plasma triglyceride measured in 1979 (r>s = –0.34, P = 0.001). BMI (r>s = –0.29, P = 0.002) and systolic blood pressure, both measured in 1979 (r>s = –0.29, P = 0.002) were associated negatively with ISI>adult. In women, plasma HDLC measured in 1979 was associated positively and significantly with ISI>adult (r>s = 0.21, P = 0.024) and BMI measured in 1979 was associated significantly and negatively with ISI>adult (r>s = –0.22, P = 0.018). Plasma triglyceride or systolic blood pressure, both measured in 1979, were not associated with ISI>adult. In gender-stratified multiple-regression analyses [controlling for waist circumference>adultmaximal aerobic capacity (VO>2max>adult), age and women's use of oral contraceptives], plasma HDLC measured in 1979 was associated significantly with ISI>adult in men (P = 0.026) but not in women (P = 0.066). A negative association was found between plasma triglyceride measured in 1979 and ISI>adult (P = 0.045) in men, but not in women (P = 0.30). BMI, total cholesterol and systolic and diastolic blood pressure, all measured in 1979, were not associated with ISI>adult. Conclusion Low plasma HDLC, high plasma triglyceride and high BMI in childhood are associated with low insulin-sensitivity index values in young adulthood.

    OriginalsprogEngelsk
    Sider (fra-til)427-433
    Antal sider7
    TidsskriftEuropean Journal of Cardiovascular Prevention & Rehabilitation
    Vol/bind3
    Udgave nummer5
    DOI
    StatusUdgivet - okt. 1996

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