Association of a microsatellite in FASL to type II diabetes and of the FAS-670G> A genotype to insulin resistance

R. L. Nolsøe, Y. H. Hamid, F. Pociot, S. Paulsen, K. M. Andersen, K. Borch-Johnsen, T. Drivsholm, T. Hansen, O. Pedersen, T. Mandrup-Poulsen*

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Type II diabetes is caused by a failure of the pancreatic β-cells to compensate for insulin resistance leading to hyperglycaemia. There is evidence for an essential role of an increased β-cell apoptosis in type II diabetes. High glucose concentrations induce IL-β production in human β-cells, Fas expression and concomitant apoptosis owing to a constitutive expression of FasL. FASL and FAS map to loci linked to type II diabetes and estimates of insulin resistance, respectively. We have tested two functional promoter polymorphisms, FAS-670 G> A and FASL-844C> T as well as a microsatellite in the 3′ UTR of FASL for association to type II diabetes in 549 type II diabetic patients and 525 normal-glucose-tolerant (NGT) control subjects. Furthermore, we have tested these polymorphisms for association to estimates of β-cell function and insulin resistance in NGT subjects. We found significant association to type II diabetes for the allele distribution of the FASL microsatellite (P-value 0.02, Bonferroni corrected). The FAS-670G> A was associated with homeostasis model assessment insulin resistance index and body mass index (P-values 0.02 and 0.02). We conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects.

    OriginalsprogEngelsk
    Sider (fra-til)316-321
    Antal sider6
    TidsskriftGenes and Immunity
    Vol/bind7
    Udgave nummer4
    DOI
    StatusUdgivet - 1 jun. 2006

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Association of a microsatellite in FASL to type II diabetes and of the FAS-670G> A genotype to insulin resistance' indeholder.

    Citationsformater