Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome

T. V.F. Hviid, S. Hylenius, A. Lindhard, O. B. Christiansen

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    To determine if a 14-bp deletion/insertion polymorphism in the 3′-untranslated region of exon 8 of the gene encoding human leukocyte antigen (HLA)-G in a homozygous form is associated with repeated, unsuccessful in vitro fertilization (IVF) treatments, and with increased risk of recurrent spontaneous abortions (RSA), 29 white women undergoing IVF treatments, 61 RSA women and 93 fertile controls were HLA-G genotype. The HLA-G genotype, homozygous for the presence of the 14 bp sequence in exon 8, was significantly associated with reduced fertility with respect to unsuccessful IVF treatments and increased risk of recurrent miscarriage (combined P < 0.01). The 14-bp insertion/deletion polymorphism is associated with differences in HLA-G mRNA alternative splicing and levels of HLA-G. This might affect a possible immunomodulatory role of HLA-G expression in both the mother and foetus during implantation and pregnancy.

    OriginalsprogEngelsk
    Sider (fra-til)66-69
    Antal sider4
    TidsskriftTissue Antigens
    Vol/bind64
    Udgave nummer1
    DOI
    StatusUdgivet - 1 jul. 2004

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome' indeholder.

    Citationsformater