Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Z. Shamim, K. Müller, A. Svejgaard, L. K. Poulsen, U. Bodtger, L. P. Ryder

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Rα. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

    OriginalsprogEngelsk
    Sider (fra-til)149-151
    Antal sider3
    TidsskriftInternational Journal of Immunogenetics
    Vol/bind34
    Udgave nummer3
    DOI
    StatusUdgivet - 1 jun. 2007

    Fingeraftryk Udforsk hvilke forskningsemner 'Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy' indeholder.

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