Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Z. Shamim; K. Müller; A. Svejgaard; L. K. Poulsen; U. Bodtger; L. P. Ryder

doi:10.1111/j.1744-313X.2007.00657.x

Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Z. Shamim^*, K. Müller, A. Svejgaard, L. K. Poulsen, U. Bodtger, L. P. Ryder

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Rα. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

Originalsprog	Engelsk
Sider (fra-til)	149-151
Antal sider	3
Tidsskrift	International Journal of Immunogenetics
Vol/bind	34
Udgave nummer	3
DOI	https://doi.org/10.1111/j.1744-313X.2007.00657.x
Status	Udgivet - 1 jun. 2007

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author = "Z. Shamim and K. M{\"u}ller and A. Svejgaard and Poulsen, {L. K.} and U. Bodtger and Ryder, {L. P.}",

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AU - Shamim, Z.

AU - Müller, K.

AU - Svejgaard, A.

AU - Poulsen, L. K.

AU - Bodtger, U.

AU - Ryder, L. P.

PY - 2007/6/1

Y1 - 2007/6/1

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AB - Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Rα. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

UR - http://www.scopus.com/inward/record.url?scp=34248569493&partnerID=8YFLogxK

U2 - 10.1111/j.1744-313X.2007.00657.x

DO - 10.1111/j.1744-313X.2007.00657.x

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JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

SN - 1744-3121

IS - 3

ER -

Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Abstract

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