Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Z. Shamim; K. Müller; A. Svejgaard; L. K. Poulsen; U. Bodtger; L. P. Ryder

doi:10.1111/j.1744-313X.2007.00657.x

Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy

Z. Shamim, K. Müller, A. Svejgaard, L. K. Poulsen, U. Bodtger, L. P. Ryder

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstrakt

Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Rα. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

Originalsprog	Engelsk
Sider (fra-til)	149-151
Antal sider	3
Tidsskrift	International Journal of Immunogenetics
Vol/bind	34
Udgave nummer	3
DOI	https://doi.org/10.1111/j.1744-313X.2007.00657.x
Status	Udgivet - 1 jun. 2007

Adgang til dokumentet

10.1111/j.1744-313X.2007.00657.x

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http://www.scopus.com/inward/record.url?scp=34248569493&partnerID=8YFLogxK

Fingeraftryk Udforsk hvilke forskningsemner 'Association between genetic polymorphisms in the human interleukin-7 receptor α-chain and inhalation allergy' indeholder.

Citationsformater

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AU - Müller, K.

AU - Svejgaard, A.

AU - Poulsen, L. K.

AU - Bodtger, U.

AU - Ryder, L. P.

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AB - Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Rα. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

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