Association between an interleukin-13 promoter polymorphism and atopy

T. Hummelshoj, U. Bodtger, P. Datta, H. J. Malling, A. Oturai, L. K. Poulsen, L. P. Ryder, P. S. Sorensen, E. Svejgaard, A. Svejgaard

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    Abstrakt

    Several studies indicate genetic involvement of Th2 cytokines in allergic diseases. Interleukin (IL)-13 has been mapped to the cytokine cluster on chromosome 5q31-33, which has been associated with atopic conditions. Recently, an association was reported between the T allele in a promoter polymorphism in the IL-13 gene (C to T exchange) at position -1055 and allergic asthma in a population study in the Netherlands. This observation was apparently confirmed in a case-control study using probands and spouses from a Dutch asthma family study, but the polymorphism in that study was reported to occur at position -1111. In the present study, we established that this polymorphism is located at position -1024 relative to the ATG translation initiation codon, and investigated whether it confers a genetic predisposition to atopic conditions and the Th1 condition multiple sclerosis (MS) in Caucasian subjects. We confirmed the association between the IL-13 -1024TT genoype and inhalation allergy (P = 2.4E-02). By combining the data from the three studies, we demonstrated a strong association (P = 1.09E-05) between the IL-13 -1024 marker and inhalation allergy. Furthermore, we showed for the first time that this association also exists in atopic dermatitis (P = 2.0E-02). No association with MS was found.

    OriginalsprogEngelsk
    Sider (fra-til)355-359
    Antal sider5
    TidsskriftEuropean Journal of Immunogenetics
    Vol/bind30
    Udgave nummer5
    DOI
    StatusUdgivet - 1 okt. 2003

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