Assessment of subclinical atherosclerosis in hidradenitis suppurativa

J. C. Pascual, I. González, D. Corona, P. Hispán, J. M. Ramos, J. Sánchez-Paya, G. B. Jemec

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Abstrakt

Background: Patients with hidradenitis suppurativa (HS) have an increased prevalence of traditional cardiovascular risk factors. Objective: Our aim was to investigate the association between subclinical atherosclerosis, detected by carotid ultrasound, and HS. Methods: A prospective observation and analytical study assessing subclinical atherosclerosis using carotid ultrasound in patients with HS. Results: A total of 62 HS patients and 62 matched controls were studied. Diabetes mellitus (22.6% vs. 6.5%, P = 0.020), hypertension (41.9% vs. 12.9%, P < 0.001) and metabolic syndrome (MetS) (38.7% vs. 8.1%, P < 0.001) were more common in HS patients. Elevated neutrophil-to-lymphocyte ratio (59.7% vs. 40.3%, P = 0.031), high-sensitivity C-reactive protein (61.1 vs. 29.0%, P < 0.001) and erythrocyte sedimentation rate (46.8% vs. 9.7%, P < 0.001) were more frequent in patients with HS. Subclinical atherosclerosis was present in 30.6% of HS patients and in 16.1% of the controls subjects (P = 0.06). After a logistic regression analysis, elevated age was associated with the presence of subclinical atherosclerosis (P < 0.001), and HS showed a tendency towards this association [adjusted OR (95% CI) 3.8 (0.9–16.0), P = 0.066]. This association was statistically significant between patients 40 years and older [OR (95% CI) 4.9 (1.8–13.1)]. Conclusions: Our clinical results indicate that patients with HS have a higher prevalence of subclinical atherosclerosis than expected when correcting for traditional risk factors. The findings support the conclusions of previous epidemiological studies.

OriginalsprogEngelsk
Sider (fra-til)1229-1238
Antal sider10
TidsskriftJournal of the European Academy of Dermatology and Venereology
Vol/bind31
Udgave nummer7
DOI
StatusUdgivet - jul. 2017

Fingeraftryk Udforsk hvilke forskningsemner 'Assessment of subclinical atherosclerosis in hidradenitis suppurativa' indeholder.

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