Aspects of haemostatic function in healthy subjects with microalbuminuria - A potential atherosclerotic risk factor

Jan Skov Jensen, Bjarne Myrup, Knut Borch-Johnsen, Gorm Jensen, Tonny Jensen, Bo Feldt-Rasmussen

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    Abstrakt

    Microalbuminuria, i.e., slightly elevated urinary albumin excretion rate (UAER), notifies increased risk for atherosclerotic disease and may reflect an early generalized vascular abnormality in healthy subjects. This study was designed in order to examine whether such abnormality is associated with a shift of the haemostatic balance in prothrombotic direction. The following haemostatic factors were measured in two representative groups of clinically healthy subjects, 28 with microalbuminuria (UAER of 6.6-150 μg/min) and 60 age- and sex-matched controls with normoalbuminuria (UAER < 6.6 μg/min): Coagulation factors: blood platelet count and mean volume, plasma Factor VII antigen concentration and coagulant activity, and plasma concentrations of prothrombin fragment 1+2, thrombin-antithrombin III complexes, fibrinogen, and fibrinopeptide A; fibrinolytic and endothelial factors: plasma concentrations of tissue plasminogen activator antigen and plasminogen activator inhibitor type 1 antigen; and endothelial factor: plasma von Willebrand factor antigen concentration. The fibrinolytic and endothelial factors were measured both before and after 10 minutes of venous occlusion of the arm. None of the haemostatic factors were significantly altered in the microalbuminuric group. Plasma fibrinogen concentration tended to be elevated but not statistically significant ((mean (95% C.I.) 7.8 (7.2-8.3) vs. 7.2 (6.9-7.5) μmol/l; p<0.1). Neither did any of the haemostatic factors correlate with UAER in regression analyses. It is concluded that the haemostatic balance is unaltered in healthy subjects with microalbuminuria. It is unlikely that a prothrombotic state is present as an intermedial factor early in a causal chain between microalbuminuria and atherosclerotic vascular disease.

    OriginalsprogEngelsk
    Sider (fra-til)423-430
    Antal sider8
    TidsskriftThrombosis Research
    Vol/bind77
    Udgave nummer5
    DOI
    StatusUdgivet - 1 mar. 1995

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