TY - JOUR
T1 - Artifact in bone mineral measurements during a very low calorie diet
T2 - Short-term effects of growth hormone
AU - Vestergaard, Peter
AU - Børglum, Jens
AU - Heickendorff, Lene
AU - Mosekilde, Leif
AU - Richelsen, Bjørn
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Short-term effects of growth hormone on bone metabolism and soft tissue collagen metabolism during weight loss in obese subjects on a very low calorie diet were investigated in a double-blind, placebo-controlled design. Twenty healthy, obese women (body mass index between 33 and 45 kg/m2) aged 21-48 yr were followed for 8 wk: half received growth hormone. A 740-kcal diet was administered the first 4 wk, followed by a 1200-kcal diet. Lumbar spine body mineral context (BMC), total-body fat mass, total-body lean body mass, total-body BMC, and total-body bone area were measured by dual-energy X-ray absorptiometry along with biochemical markers of bone turnover. The body weight decreased by 5.5% and fat mass by 11.4%. There were no changes in biochemical bone markers in the placebo group despite a marked decrease in BMC (3.1%). Projected total bone area decreased proportional to BMC (r2 = 0.89) during the weight loss. Growth hormone treatment did not modulate the decrease in lean body mass, body weight, fat mass, or BMC, but increased bone turnover markers. Growth hormone did not change the results concerning BMC, projected bone area, BMD, lean body mass, or fat mass. Because 89% of the observed change in BMC could be explained by alterations in projected bone area without changes in biochemical bone markers, it is concluded that a large part of the observed decrease in BMC during weight loss may be caused by scanner artifact.
AB - Short-term effects of growth hormone on bone metabolism and soft tissue collagen metabolism during weight loss in obese subjects on a very low calorie diet were investigated in a double-blind, placebo-controlled design. Twenty healthy, obese women (body mass index between 33 and 45 kg/m2) aged 21-48 yr were followed for 8 wk: half received growth hormone. A 740-kcal diet was administered the first 4 wk, followed by a 1200-kcal diet. Lumbar spine body mineral context (BMC), total-body fat mass, total-body lean body mass, total-body BMC, and total-body bone area were measured by dual-energy X-ray absorptiometry along with biochemical markers of bone turnover. The body weight decreased by 5.5% and fat mass by 11.4%. There were no changes in biochemical bone markers in the placebo group despite a marked decrease in BMC (3.1%). Projected total bone area decreased proportional to BMC (r2 = 0.89) during the weight loss. Growth hormone treatment did not modulate the decrease in lean body mass, body weight, fat mass, or BMC, but increased bone turnover markers. Growth hormone did not change the results concerning BMC, projected bone area, BMD, lean body mass, or fat mass. Because 89% of the observed change in BMC could be explained by alterations in projected bone area without changes in biochemical bone markers, it is concluded that a large part of the observed decrease in BMC during weight loss may be caused by scanner artifact.
KW - Bone mineral density
KW - Bone turnover
KW - Very low calorie diet
UR - http://www.scopus.com/inward/record.url?scp=0034054202&partnerID=8YFLogxK
U2 - 10.1385/JCD:3:1:063
DO - 10.1385/JCD:3:1:063
M3 - Article
C2 - 10745303
AN - SCOPUS:0034054202
VL - 3
SP - 63
EP - 71
JO - Journal of Clinical Densitometry
JF - Journal of Clinical Densitometry
SN - 1094-6950
IS - 1
ER -