Aortahomograftoperationer ved svær endokarditis

Signe Foghsgaard, Niels Eske Bruun, Henrik Kåre Kjærgård

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Introduction: Severe endocarditis of the native aortic valve or a prosthetic valve with destruction of the cusps, paravalvular abscess formation and/or fistulas caused by aggressive bacteria has a mortality of almost 100% without surgery. The objective was to evaluate the results of treatment with an aortic homograft in combination with antibiotics. Materials and methods: 24 patients with either aortic prosthetic valve endocarditis (n = 16) or severe aortic endocarditis (n = 8) were operated with implantation of an aortic homograft at a Danish university hospital from 1997-2006. Staphylococcus species were the most common pathogens followed by streptococcus. Intravenous antibiotic therapy was started before surgery and continued for 4-6 weeks. The patients were followed-up for 1/2 -10 years (mean 5 years). Results: 3 patients with prosthetic valve endocarditis died within the first 24 hours from heart failure. 2 of these patients required in addition implantation of mitral valve prostheses. 5 patients died 1-7 years after the operation from non-cardiac causes. Within the follow-up period no patients had relapse of endocarditis, and only one episode of recurrence endocarditis in an intravenous drug abuser was registered after 4 years. Conclusion: An aortic homograft in combination with intravenous antibiotics is an excellent treatment of severe endocarditis in the aortic valve or an aortic valve prosthesis.

    Bidragets oversatte titelOutcome of aortic homograft implantation in severe endocarditis
    Sider (fra-til)1646-1650
    Antal sider5
    TidsskriftUgeskrift for laeger
    Udgave nummer19
    StatusUdgivet - 5 maj 2008


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