Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis

Regitze Sølling Wils, Ditte Resendal Gotfredsen, Carsten Hjorthøj, Stephen F Austin, Nikolai Albert, Rikke Gry Secher, Anne Amalie Elgaard Thorup, Ole Mors, Merete Nordentoft

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.

    METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.

    FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.

    CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

    OriginalsprogEngelsk
    Sider (fra-til)42-48
    Antal sider7
    TidsskriftSchizophrenia Research
    Vol/bind182
    DOI
    StatusUdgivet - apr. 2017

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    Copyright © 2016 Elsevier B.V. All rights reserved.

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