Antimicrobial susceptibility and β-lactamase characterization of Branhamella catarrhalis isolates from 1983/1984 and 1988

J. J. Christensen, J. Keiding, B. Bruun*

*Corresponding author af dette arbejde

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    Abstrakt

    Branhamella catarrhalis isolates from lower respiratory tract specimens collected in 1983/84 (n = 50) and 1988 (n = 30) were examined for β-lactamase production. The percent of β-lactamase-producing strains increased from 25% to 63% from 1983/84 to 1988. β-lactamases from 30 strains could be typed, and of these 28 were of the BRO-1 type and two the BRO-2 type. The two β-lactamase inhibitors, clavulanic acid and brobactam were very active against β-lactamase extracts whether of the BRO-1 or the BRO-2 type. Susceptibility to a number of antimicrobial agents or combinations of agents was determined by a plate dilution method (MICs) and by a tablet diffusion method. The penicillin tablet (Rosco Neo-Sensitabs®) was found to be useful in discriminating between β-lactamase-producing and non-β-lactamase-producing strains of B. catarrhalis.

    OriginalsprogEngelsk
    Sider (fra-til)1039-1044
    Antal sider6
    TidsskriftAPMIS
    Vol/bind98
    Udgave nummer11
    StatusUdgivet - 1 jan. 1990

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