Antiemetic Effects of Ondansetron and Metopimazine

Jorn Herrstedt, Tine Sigsgaard, Per Dombernowsky

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    To the Editor: The conclusion of Herrstedt et al. (April 15 issue)1 that “ondansetron plus metopimazine is a highly effective and safe antiemetic regimen that is markedly superior to treatment with ondansetron alone in patients receiving moderately emetogenic chemotherapy” is misleading. The primary end point of antiemetic treatment is complete protection from vomiting and nausea, not the mean number of emetic episodes and the mean score of nausea. These are generally evaluated as secondary end points. Considering the data on complete protection from vomiting as marginals of a two-by-two table, we found that the two-sided McNemar test indicated no significance…

    Sider (fra-til)1356-1357
    Antal sider2
    TidsskriftNew England Journal of Medicine
    Udgave nummer18
    StatusUdgivet - 28 okt. 1993

    Fingeraftryk Udforsk hvilke forskningsemner 'Antiemetic Effects of Ondansetron and Metopimazine' indeholder.