Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

Lise M Lindahl, Andreas Willerslev-Olsen, Lise M R Gjerdrum, Pia R Nielsen, Edda Blümel, Anne H Rittig, Pamela Celis, Bjorn Herpers, Jürgen C Becker, Birgitte Stausbøl-Grøn, Mariusz A Wasik, Maria Gluud, Simon Fredholm, Terkild B Buus, Claus Johansen, Claudia Nastasi, Lukas Peiffer, Linda Kubat, Michael Bzorek, Jens O EriksenThorbjørn Krejsgaard, Charlotte M Bonefeld, Carsten Geisler, Tomas Mustelin, Erik Langhoff, Michael Givskov, Anders Woetmann, Mogens Kilian, Thomas Litman, Lars Iversen*, Niels Odum

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


It has been proposed that CD4 T-cell responses to Staphylococcus aureus (SA) can inadvertently enhance neoplastic progression in models of skin cancer and cutaneous T-cell lymphoma (CTCL). In this prospective study, we explored the effect of transient antibiotic treatment on tumor cells and disease activity in 8 patients with advanced-stage CTCL. All patients experienced significant decrease in clinical symptoms in response to aggressive, transient antibiotic treatment. In some patients, clinical improvements lasted for more than 8 months. In 6 of 8 patients, a malignant T-cell clone could be identified in lesional skin, and a significant decrease in the fraction of malignant T cells was observed following antibiotics but an otherwise unchanged treatment regimen. Immunohistochemistry, global messenger RNA expression, and cell-signaling pathway analysis indicated that transient aggressive antibiotic therapy was associated with decreased expression of interleukin-2 high-affinity receptors (CD25), STAT3 signaling, and cell proliferation in lesional skin. In conclusion, this study provides novel evidence suggesting that aggressive antibiotic treatment inhibits malignant T cells in lesional skin. Thus, we provide a novel rationale for treatment of SA in advanced CTCL.

Sider (fra-til)1072-1083
Antal sider12
Udgave nummer13
StatusUdgivet - 26 sep. 2019


Udforsk hvilke forskningsemner 'Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma' indeholder.