Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives; A case report

Thomas Idorn*, Lone Schejbel, Casper Rydahl, James Goya Heaf, Karen Riis Jølvig, Marie Bergstrøm, Peter Garred, Anne Lise Kamper

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    Background: Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy are rare diseases with no known coherence. Case Presentation: A daughter and her biological mother were diagnosed with pregnancy-induced thrombotic microangiopathy and anti-glomerular basement membrane glomerulonephritis, respectively. Both developed end-stage renal disease. Exploration of a common aetiology included analyses of HLA genotypes, functional and genetic aspects of the complement system, ADAMTS13 activity and screening for autoantibodies. The daughter was heterozygous carrier of the complement factor I G261D mutation, previously described in patients with membranoproliferative glomerulonephritis and atypical haemolytic uremic syndrome. The mother was non-carrier of this mutation. They shared the disease associated complement factor H silent polymorphism Q672Q (79602A>G). Conclusion: An unequivocal functional or molecular association between these two family cases was not found suggesting that the patients probably share another, so far undiagnosed and unknown, predisposing factor. It seems highly unlikely that two infrequent immunologic diseases would occur by unrelated pathophysiological mechanisms within first degree relatives.

    OriginalsprogEngelsk
    Artikelnummer64
    TidsskriftBMC Nephrology
    Vol/bind13
    Udgave nummer1
    DOI
    StatusUdgivet - 30 jul. 2012

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives; A case report' indeholder.

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