TY - JOUR
T1 - ANP and BNP in atrial fibrillation before and after cardioversion--and their relationship to cardiac volume and function
AU - Therkelsen, Susette Krohn
AU - Groenning, Bjoern Aaris
AU - Kjaer, Andreas
AU - Svendsen, Jesper Hastrup
AU - Boje Jensen, Gorm
PY - 2008/7/21
Y1 - 2008/7/21
N2 - The role of atrial (ANP) and B-type (BNP) natriuretic peptide in atrial fibrillation (AF) is not clear. Our aim was to describe ANP and BNP in AF, and their changes following cardioversion in persistent AF. Furthermore, we wanted to assess the association between ANP and BNP and cardiac volume and function evaluated by magnetic resonance imaging. ANP and BNP decreased significantly following cardioversion. After 180 days of sinus rhythm, ANP and BNP were still significantly elevated. Same results were seen in patients with lone AF. Left and right atrial volumes correlated positively with ANP and BNP. Changes in left atrial volume were predictive of changes in ANP and BNP following cardioversion. AF may cause enduringly elevated ANP and BNP and atrial volume seems to be an important determinant of ANP and BNP in AF.
AB - The role of atrial (ANP) and B-type (BNP) natriuretic peptide in atrial fibrillation (AF) is not clear. Our aim was to describe ANP and BNP in AF, and their changes following cardioversion in persistent AF. Furthermore, we wanted to assess the association between ANP and BNP and cardiac volume and function evaluated by magnetic resonance imaging. ANP and BNP decreased significantly following cardioversion. After 180 days of sinus rhythm, ANP and BNP were still significantly elevated. Same results were seen in patients with lone AF. Left and right atrial volumes correlated positively with ANP and BNP. Changes in left atrial volume were predictive of changes in ANP and BNP following cardioversion. AF may cause enduringly elevated ANP and BNP and atrial volume seems to be an important determinant of ANP and BNP in AF.
KW - Atrial Fibrillation/blood
KW - Atrial Function/physiology
KW - Atrial Natriuretic Factor/blood
KW - Cardiac Volume/physiology
KW - Electric Countershock/methods
KW - Humans
KW - Natriuretic Peptide, Brain/blood
KW - Time Factors
KW - Ventricular Function/physiology
U2 - 10.1016/j.ijcard.2007.04.059
DO - 10.1016/j.ijcard.2007.04.059
M3 - Letter
C2 - 17628724
SN - 0167-5273
VL - 127
SP - 396
EP - 399
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -