Analgesic effects of melatonin: A review of current evidence from experimental and clinical studies

Michael Wilhelmsen, Ilda Amirian*, Russel J. Reiter, Jacob Rosenberg, Ismail Gögenur

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin shows potent analgesic effects in a dose-dependent manner. In clinical studies, melatonin has been shown to have analgesic benefits in patients with chronic pain (fibromyalgia, irritable bowel syndrome, migraine). The physiologic mechanism underlying the analgesic actions of melatonin has not been clarified. The effects may be linked to G i-coupled melatonin receptors, to G i-coupled opioid μ-receptors or GABA-B receptors with unknown downstream changes with a consequential reduction in anxiety and pain. Also, the repeated administration of melatonin improves sleep and thereby may reduce anxiety, which leads to lower levels of pain. In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain.

    OriginalsprogEngelsk
    Sider (fra-til)270-277
    Antal sider8
    TidsskriftJournal of Pineal Research
    Vol/bind51
    Udgave nummer3
    DOI
    StatusUdgivet - 1 okt. 2011

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