An evaluation of fundus photography and fundus autofluorescence in the diagnosis of cuticular drusen

Tracy B. Høeg*, Birgitte Moldow, Ronald Klein, Morten La Cour, Kristian Klemp, Ditte Erngaard, Christina Ellervik, Helena Buch

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Purpose To examine non-mydriatic fundus photography (FP) and fundus autofluorescence (FAF) as alternative non-invasive imaging modalities to fluorescein angiography (FA) in the detection of cuticular drusen (CD). Methods Among 2953 adults from the Danish Rural Eye Study (DRES) with gradable FP, three study groups were selected: (1) All those with suspected CD without age-related macular degeneration (AMD) on FP, (2) all those with suspected CD with AMD on FP and (3) a randomly selected group with early AMD. Groups 1, 2 and 3 underwent FA and FAF and group 4 underwent FAF only as part of DRES CD substudy. Main outcome measures included percentage of correct positive and correct negative diagnoses, Cohen's κ and prevalenceadjusted and bias-adjusted κ (PABAK) coefficients of test and grader reliability. Results CD was correctly identified on FP 88.9% of the time and correctly identified as not being present 83.3% of the time. CD was correctly identified on FAF 62.0% of the time and correctly identified as not being present 100.0% of the time. Compared with FA, FP has a PABAK of 0.75 (0.60 to 1.5) and FAF a PABAK of 0.44 (0.23 to 0.95). Conclusions FP is a promising, non-invasive substitute for FA in the diagnosis of CD. FAF was less reliable than FP to detect CD.

OriginalsprogEngelsk
Sider (fra-til)378-382
Antal sider5
TidsskriftBritish Journal of Ophthalmology
Vol/bind100
Udgave nummer3
DOI
StatusUdgivet - mar. 2016

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Udforsk hvilke forskningsemner 'An evaluation of fundus photography and fundus autofluorescence in the diagnosis of cuticular drusen' indeholder.

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