TY - GEN
T1 - An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders
AU - Steinmann, Tobias P.
AU - Andrew, Colin M.
AU - Thomsen, Carsten E.
AU - Kjar, Troels W.
AU - Meintjes, Ernesta M.
AU - Molteno, Christopher D.
AU - Jacobson, Joseph B.
AU - Jacobson, Sandra W.
AU - Sorensen, Helge B.D.
PY - 2011/12/26
Y1 - 2011/12/26
N2 - In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12.8 years (11 years to 14.7 years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n 11). The children were instructed to push a button in response to the Go stimulus and not to press the button when the No Go stimulus were heard. Task performance accuracy did not differ between the two groups, however differences were observed in the ERP components: P2, N2, and P3. The P2 amplitude were larger for Go trials in both groups. The FAS/PFAS group showed slower N2 response to Go trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs.
AB - In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12.8 years (11 years to 14.7 years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n 11). The children were instructed to push a button in response to the Go stimulus and not to press the button when the No Go stimulus were heard. Task performance accuracy did not differ between the two groups, however differences were observed in the ERP components: P2, N2, and P3. The P2 amplitude were larger for Go trials in both groups. The FAS/PFAS group showed slower N2 response to Go trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs.
UR - http://www.scopus.com/inward/record.url?scp=84861953092&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2011.6090181
DO - 10.1109/IEMBS.2011.6090181
M3 - Conference contribution
C2 - 22254429
AN - SCOPUS:84861953092
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 789
EP - 792
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -