Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

Lars Arendt-Nielsen*, Søren T. Skou, Thomas A. Nielsen, Kristian K. Petersen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review


    Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanisms are not fully understood, and safe and efficient analgesic drugs are not available. The pain associated with joint pain is highly individual, and features from radiological imaging have not demonstrated robust associations with the pain manifestations. In recent years, a variety of human quantitative pain assessment tools (quantitative sensory testing (QST)) have been developed providing new opportunities for profiling patients and reaching a greater understanding of the mechanisms involved in chronic joint pain. As joint pain is a complex interaction between many different pain mechanisms, available tools are important for patent profiling and providing the basic knowledge for development of new drugs and for developing pain management regimes.

    Sider (fra-til)225-234
    Antal sider10
    TidsskriftCurrent Osteoporosis Reports
    Udgave nummer4
    StatusUdgivet - 2 aug. 2015


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