Alcohol-related morbidity and mortality within siblings

Grethe Søndergaard, Merete Osler, Anne Marie Nybo Andersen, Per Kragh Andersen, Susanne Oksbjerg Dalton, Laust H. Mortensen

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    Abstrakt

    Aims: To estimate the association between educational status and alcohol-related somatic and non-somatic morbidity and mortality among full siblings in comparison with non-related individuals. Design: Cohort study. Setting: Denmark. Participants: Approximately 1.4 million full siblings born in Denmark between 1950 and 1979 were followed from age 28-58years or censoring due to alcohol-related hospitalization and mortality. Measurements: Cox regression analyses were used to estimate associations of educational status with alcohol-related outcomes. Results from cohort analyses based on non-related individuals and inter-sibling analyses were compared. Findings: A lower educational status was associated with a higher rate of alcohol-related outcomes, especially among the youngest (aged 28-37 years) and individuals born 1970-79. Compared with the cohort analyses, the associations attenuated slightly in the inter-sibling analysis. For example, in the cohort analysis, females with a basic school education born 1970-79 had an increased rate of alcohol-related non-somatic morbidity and mortality [hazard rate ratio (HR)=4.05, 95% confidence interval (CI)=3.27-5.02] compared to those with a vocational education. In the inter-sibling analysis, the HR attenuated (HR=2.66, 95% CI=1.95-3.63). For alcohol-related somatic outcomes the corresponding figures were HR=3.47 (95% CI=2.63-4.58) and HR=3.36 (95% CI=2.10-5.38), respectively. In general, the associations were stronger among females than males (aged 28-37) in the analyses of alcohol-related non-somatic outcomes. Health conditions earlier in life explained only a minor part of the associations. Conclusions: The association between educational status and alcohol-related somatic and non-somatic morbidity and mortality is only driven by familial factors to a small degree.

    OriginalsprogEngelsk
    Sider (fra-til)451-460
    Antal sider10
    TidsskriftAddiction
    Vol/bind110
    Udgave nummer3
    DOI
    StatusUdgivet - 1 mar. 2015

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