Albuminuria reflects widespread vascular damage - The Steno hypothesis

T. Deckert*, B. Feldt-Rasmussen, K. Borch-Johnsen, T. Jensen, A. Kofoed-Enevoldsen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstract

    Albuminuria in Type 1 (insulin-dependent) diabetes is not only an indication of renal disease, but a new, independent risk-marker of proliferative retinopathy and macroangiopathy. The coincidence of generalised vascular dysfunction and albuminuria, advanced mesangial expansion, proliferative retinopathy, and severe macroangiopathy suggests a common cause of albuminuria and the severe renal and extrarenal complications associated with it. Enzymes involved in the metabolism of anionic components of the extracellular matrix (e.g. heparan sulphate proteoglycan) vulnerable to hyperglycaemia, seem to constitute the primary cause of albuminuria and the associated complications. Genetic polymorphism of such enzymes is possibly the main reason for variation in susceptibility.

    OriginalsprogEngelsk
    Sider (fra-til)219-226
    Antal sider8
    TidsskriftDiabetologia
    Vol/bind32
    Udgave nummer4
    DOI
    StatusUdgivet - 1 apr. 1989

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