Akut trombotisk komplikation ved debut af det Philadelphia-kromosom-negative myeloproliferative syndrom

Hans Carl Hasselbalch*, Hans Torben Mourits-Andersen, Bjarne Anker Jensen, Morten Krogh Jensen, Ove Juul Nielsen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Methods: We describe eight patients with a diagnosis of a chronic myeloproliferative disorder, characterised in most patients by severe thrombotic complications at the debut of the disease. Results: The symptoms were life-threatening in seven patients: acute upper gastrointestinal haemorrhage from oesophageal varices in four, an acute abdominal catastrophy owing to mesenteric vein thrombosis with intestinal gangrene in two, and a large cerebral infarction, which was lethal, in one. The same patient also suffered a thrombosis of the axillary and subclavian veins. Neurological symptoms, with headache, visual disturbances, dizziness, and impaired memory, were initial cardinal symptoms. In two patients, explorative laparotomy was performed with intestinal resection owing to gangrene. One patient had a toe amputation. Discussion: The above symptoms are explained by thrombosis in the microcirculation because of thrombocytosis and circulating platelet aggregates. In patients with polycythaemia vera, the elevated haematocrit contributes significantly to the impaired microcirculation. Early diagnosis and management of these disorders are of utmost importance to prevent the potentially life-threatening complications described above.

    Bidragets oversatte titelAcute thrombotic complication at the debut of the Philadelphia chromosome-negative myeloproliferative syndrome
    Sider (fra-til)2478-2481
    Antal sider4
    TidsskriftUgeskrift for laeger
    Udgave nummer18
    StatusUdgivet - 30 apr. 2001


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