Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project

Konstantina Dimakopoulou, Evangelia Samoli, Rob Beelen, Massimo Stafoggia, Zorana Jovanovic Andersen, Barbara Hoffmann, Paul Fischer, Mark Nieuwenhuijsen, Paolo Vineis, Wei Xun, Gerard Hoek, Ole Raaschou-Nielsen, Anna Oudin, Bertil Forsberg, Lars Modig, Pekka Jousilahti, Timo Lanki, Anu Turunen, Bente Oftedal, Per NafstadPer E. Schwarze, Johanna Penell, Laura Fratiglioni, Niklas Andersson, Nancy Pedersen, Michal Korek, Ulf De Faire, Kirsten Thorup Eriksen, Anne Tjønneland, Thomas Becker, Meng Wang, Bas Bueno-De-Mesquita, Ming Yi Tsai, Marloes Eeftens, Petra H. Peeters, Kees Meliefste, Alessandro Marcon, Ursula Krämer, Thomas A.J. Kuhlbusch, Mohammad Vossoughi, Timothy Key, Kees De Hoogh, Regina Hampel, Annette Peters, Joachim Heinrich, Gudrun Weinmayr, Hans Concin, Gabriele Nagel, Alex Ineichen, Bénédicte Jacquemin, Morgane Stempfelet, Alice Vilier, Fulvio Ricceri, Carlotta Sacerdote, Xanthi Pedeli, Michalis Katsoulis, Antonia Trichopoulou, Bert Brunekreef, Klea Katsouyanni*

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratorymortality.

    Sider (fra-til)684-696
    Antal sider13
    TidsskriftAmerican Journal of Respiratory and Critical Care Medicine
    Udgave nummer6
    StatusUdgivet - 15 mar. 2014


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