Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA Findings

Guiseppe Rossi; Jon Salmanton-García; Chiara Cattaneo; Francesco Marchesi; Julio Dávila-Valls; Sonia Martín-Pérez; Federico Itri; Alberto López-García; Andreas Glenthøj; Maria Gomes da Silva; Caroline Besson; Monia Marchetti; Barbora Weinbergerová; Ozren Jaksic; Moraima Jiménez; Yavuz M Bilgin; Jaap VAN Doesum; Francesca Farina; Pavel Žák; Luisa Verga; Graham P Collins; Valentina Bonuomo; Jens VAN Praet; Marcio Nucci; Stef Meers; Ildefonso Espigado; Nicola S Fracchiolla; Toni Valković; Christian Bjørn Poulsen; Natasha Čolović; Giulia Dragonetti; Marie-Pierre Ledoux; Carlo Tascini; Caterina Buquicchio; Ola Blennow; Francesco Passamonti; Marina Machado; Jorge Labrador; Rafael F Duarte; Martin Schönlein; Lucia Prezioso; Iker Falces-Romero; Austin Kulasekararaj; Carolina Garcia-Vidal; Noemí Fernández; Ghaith Abu-Zeinah; Irati Ormazabal-Vélez; Tatjana Adžić-Vukičević; Igor Stoma; Annarosa Cuccaro; Ditte Stampe Hersby

doi:10.1016/j.ijid.2023.10.013

Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA Findings

Guiseppe Rossi, Jon Salmanton-García^*, Chiara Cattaneo, Francesco Marchesi, Julio Dávila-Valls, Sonia Martín-Pérez, Federico Itri, Alberto López-García, Andreas Glenthøj, Maria Gomes da Silva, Caroline Besson, Monia Marchetti, Barbora Weinbergerová, Ozren Jaksic, Moraima Jiménez, Yavuz M Bilgin, Jaap VAN Doesum, Francesca Farina, Pavel Žák, Luisa VergaGraham P Collins, Valentina Bonuomo, Jens VAN Praet, Marcio Nucci, Stef Meers, Ildefonso Espigado, Nicola S Fracchiolla, Toni Valković, Christian Bjørn Poulsen, Natasha Čolović, Giulia Dragonetti, Marie-Pierre Ledoux, Carlo Tascini, Caterina Buquicchio, Ola Blennow, Francesco Passamonti, Marina Machado, Jorge Labrador, Rafael F Duarte, Martin Schönlein, Lucia Prezioso, Iker Falces-Romero, Austin Kulasekararaj, Carolina Garcia-Vidal, Noemí Fernández, Ghaith Abu-Zeinah, Irati Ormazabal-Vélez, Tatjana Adžić-Vukičević, Igor Stoma, Annarosa Cuccaro, Ditte Stampe Hersby

^*Corresponding author af dette arbejde

Hæmatologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.

METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.

RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.

CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

Originalsprog	Engelsk
Sider (fra-til)	98-110
Antal sider	13
Tidsskrift	International Journal of Infectious Diseases
Vol/bind	137
Tidlig onlinedato	18 okt. 2023
DOI	https://doi.org/10.1016/j.ijid.2023.10.013
Status	Udgivet - dec. 2023

Bibliografisk note

Adgang til dokumentet

10.1016/j.ijid.2023.10.013

Citationsformater

Rossi, G., Salmanton-García, J., Cattaneo, C., Marchesi, F., Dávila-Valls, J., Martín-Pérez, S., Itri, F., López-García, A., Glenthøj, A., Gomes da Silva, M., Besson, C., Marchetti, M., Weinbergerová, B., Jaksic, O., Jiménez, M., Bilgin, Y. M., Doesum, J. VAN., Farina, F., Žák, P., ... Hersby, D. S. (2023). Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA Findings. International Journal of Infectious Diseases, 137, 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

@article{98b765a682b24902aefe17a127f7bf03,

title = "Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA Findings",

abstract = "OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.",

keywords = "Aged, Aged, 80 and over, COVID-19, Female, Hematologic Neoplasms/complications, Humans, Immunization, Lymphopenia, Male, Vaccination",

author = "Guiseppe Rossi and Jon Salmanton-Garc{\'i}a and Chiara Cattaneo and Francesco Marchesi and Julio D{\'a}vila-Valls and Sonia Mart{\'i}n-P{\'e}rez and Federico Itri and Alberto L{\'o}pez-Garc{\'i}a and Andreas Glenth{\o}j and {Gomes da Silva}, Maria and Caroline Besson and Monia Marchetti and Barbora Weinbergerov{\'a} and Ozren Jaksic and Moraima Jim{\'e}nez and Bilgin, {Yavuz M} and Doesum, {Jaap VAN} and Francesca Farina and Pavel {\v Z}{\'a}k and Luisa Verga and Collins, {Graham P} and Valentina Bonuomo and Praet, {Jens VAN} and Marcio Nucci and Stef Meers and Ildefonso Espigado and Fracchiolla, {Nicola S} and Toni Valkovi{\'c} and Poulsen, {Christian Bj{\o}rn} and Natasha {\v C}olovi{\'c} and Giulia Dragonetti and Marie-Pierre Ledoux and Carlo Tascini and Caterina Buquicchio and Ola Blennow and Francesco Passamonti and Marina Machado and Jorge Labrador and Duarte, {Rafael F} and Martin Sch{\"o}nlein and Lucia Prezioso and Iker Falces-Romero and Austin Kulasekararaj and Carolina Garcia-Vidal and Noem{\'i} Fern{\'a}ndez and Ghaith Abu-Zeinah and Irati Ormazabal-V{\'e}lez and Tatjana Ad{\v z}i{\'c}-Vuki{\v c}evi{\'c} and Igor Stoma and Annarosa Cuccaro and Hersby, {Ditte Stampe}",

year = "2023",

month = dec,

doi = "10.1016/j.ijid.2023.10.013",

language = "English",

volume = "137",

pages = "98--110",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier B.V.",

}

Rossi, G, Salmanton-García, J, Cattaneo, C, Marchesi, F, Dávila-Valls, J, Martín-Pérez, S, Itri, F, López-García, A, Glenthøj, A, Gomes da Silva, M, Besson, C, Marchetti, M, Weinbergerová, B, Jaksic, O, Jiménez, M, Bilgin, YM, Doesum, JVAN, Farina, F, Žák, P, Verga, L, Collins, GP, Bonuomo, V, Praet, JVAN, Nucci, M, Meers, S, Espigado, I, Fracchiolla, NS, Valković, T, Poulsen, CB, Čolović, N, Dragonetti, G, Ledoux, M-P, Tascini, C, Buquicchio, C, Blennow, O, Passamonti, F, Machado, M, Labrador, J, Duarte, RF, Schönlein, M, Prezioso, L, Falces-Romero, I, Kulasekararaj, A, Garcia-Vidal, C, Fernández, N, Abu-Zeinah, G, Ormazabal-Vélez, I, Adžić-Vukičević, T, Stoma, I, Cuccaro, A & Hersby, DS 2023, 'Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA Findings', International Journal of Infectious Diseases, bind 137, s. 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

TY - JOUR

T1 - Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients

T2 - EPICOVIDEHA Findings

AU - Rossi, Guiseppe

AU - Salmanton-García, Jon

AU - Cattaneo, Chiara

AU - Marchesi, Francesco

AU - Dávila-Valls, Julio

AU - Martín-Pérez, Sonia

AU - Itri, Federico

AU - López-García, Alberto

AU - Glenthøj, Andreas

AU - Gomes da Silva, Maria

AU - Besson, Caroline

AU - Marchetti, Monia

AU - Weinbergerová, Barbora

AU - Jaksic, Ozren

AU - Jiménez, Moraima

AU - Bilgin, Yavuz M

AU - Doesum, Jaap VAN

AU - Farina, Francesca

AU - Žák, Pavel

AU - Verga, Luisa

AU - Collins, Graham P

AU - Bonuomo, Valentina

AU - Praet, Jens VAN

AU - Nucci, Marcio

AU - Meers, Stef

AU - Espigado, Ildefonso

AU - Fracchiolla, Nicola S

AU - Valković, Toni

AU - Poulsen, Christian Bjørn

AU - Čolović, Natasha

AU - Dragonetti, Giulia

AU - Ledoux, Marie-Pierre

AU - Tascini, Carlo

AU - Buquicchio, Caterina

AU - Blennow, Ola

AU - Passamonti, Francesco

AU - Machado, Marina

AU - Labrador, Jorge

AU - Duarte, Rafael F

AU - Schönlein, Martin

AU - Prezioso, Lucia

AU - Falces-Romero, Iker

AU - Kulasekararaj, Austin

AU - Garcia-Vidal, Carolina

AU - Fernández, Noemí

AU - Abu-Zeinah, Ghaith

AU - Ormazabal-Vélez, Irati

AU - Adžić-Vukičević, Tatjana

AU - Stoma, Igor

AU - Cuccaro, Annarosa

AU - Hersby, Ditte Stampe

PY - 2023/12

Y1 - 2023/12

N2 - OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

AB - OBJECTIVES: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.METHODS: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy.RESULTS: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment.CONCLUSION: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

KW - Aged

KW - Aged, 80 and over

KW - COVID-19

KW - Female

KW - Hematologic Neoplasms/complications

KW - Humans

KW - Immunization

KW - Lymphopenia

KW - Male

KW - Vaccination

U2 - 10.1016/j.ijid.2023.10.013

DO - 10.1016/j.ijid.2023.10.013

M3 - Article

C2 - 37863310

SN - 1201-9712

VL - 137

SP - 98

EP - 110

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA Findings

Abstract

Bibliografisk note

Adgang til dokumentet

Fingeraftryk

Citationsformater