Acute cardiovascular effects of insulin in hyperglycaemic type I diabetics

P. C. Gotzsche*, H. Kelbaek, S. F. Vissing, S. L. Nielsen, O. Munck, N. J. Christensen, J. Lyngsoe, E. R. Mathiesen

*Corresponding author af dette arbejde

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    Cardiovascular responses to high-dose (0.100 IE kg-1 h-1) and low-dose insulin infusion (0.005-0.01 IE kg-1 h-1) were examined in eight hyperglycaemic, resting type I diabetics. Mean blood glucose dropped from 15.9 to 7.1 mmol l-1 and from 14.4 to 12.6 mmol l-1, respectively, during 1 h. Blood pressure and heart rate did not change. There were no significant changes in absolute or relative left ventricular volumes, the 95% confidence interval (CI) for the difference between the doses in left ventricular ejection fraction was -6 to 8%. Calf blood volume increased on high-dose insulin (p = 0.05, CI for the difference over low-dose insulin 0.0 to 4.6 ml 100 ml-1 tissue). Blood flow increased with 1.6 ml 100 ml-1 tissue min-1 with high-dose insulin and with 0.6 ml 100 ml-1 tissue min-1 with low-dose (CI for the difference -0.5 to 3.4). Noradrenaline increases were small and there was no difference between the doses (p = 0.47).

    Sider (fra-til)93-97
    Antal sider5
    TidsskriftScandinavian Journal of Clinical and Laboratory Investigation
    Udgave nummer1
    StatusUdgivet - 14 feb. 1991


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