Absence of entero- and cardioviral RNA in multiple sclerosis brain tissue

R. B. Dessau*, L. P. Nielsen, J. L. Frederiksen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    Objectives - Epidemiological evidence suggests that an infectious agent may be involved in the pathogenesis of multiple sclerosis (MS). Picornaviruses are possible candidates for an etiological agent, because of their neurotropic properties and ability to cause chronic infections. Materials and methods Autopsy brain tissue from 25 patients with clinically definite MS and 33 control patients without inflammatory neurological disease was tested with reverse transcription PCR specific for enteroviruses and cardioviruses. Results - All specimens were found negative. Conclusion - These results do not support the theory of a persisting entero- or cardioviral infection as the cause of MS as we found no evidence of the presence of entero- or cardioviral genomes in the brains from MS patients.

    OriginalsprogEngelsk
    Sider (fra-til)284-286
    Antal sider3
    TidsskriftActa Neurologica Scandinavica
    Vol/bind95
    Udgave nummer5
    DOI
    StatusUdgivet - 1 jan. 1997

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