ABO blood types and sepsis mortality

Theis S Itenov, Daniel I Sessler, Ashish K Khanna, Sisse R Ostrowski, Pär I Johansson, Christian Erikstrup, Ole B Pedersen, Sofie L Rygård, Lars B Holst, Morten H Bestle, Lars Hein, Anne Lindhardt, Hami Tousi, Mads H Andersen, Thomas Mohr, Jens D Lundgren, Jens-Ulrik Jensen

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Abstrakt

BACKGROUND: We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.

RESULTS: We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79-0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.

CONCLUSION: Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

OriginalsprogEngelsk
Sider (fra-til)61
TidsskriftAnnals of Intensive Care
Vol/bind11
Udgave nummer1
DOI
StatusUdgivet - 20 apr. 2021

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