TY - JOUR
T1 - ABO blood group and risk of cancer
T2 - A register-based cohort study of 1.6 million blood donors
AU - Vasan, Senthil K.
AU - Hwang, Jinseub
AU - Rostgaard, Klaus
AU - Nyrén, Olof
AU - Ullum, Henrik
AU - Pedersen, Ole B.V.
AU - Erikstrup, Christian
AU - Melbye, Mads
AU - Hjalgrim, Henrik
AU - Pawitan, Yudi
AU - Edgren, Gustaf
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Introduction The associations between ABO blood group and cancer risk have been studied repeatedly, but results have been variable. Consistent associations have only been reported for pancreatic and gastric cancers. Materials and methods We estimated associations between different ABO blood groups and site-specific cancer risk in a large cohort of healthy blood donors from Sweden and Denmark. Results A total of 1.6 million donors were followed over 27 million person-years (20 million in Sweden and 7 million in Denmark). We observed 119,584 cancer cases. Blood groups A, AB and B were associated either with increased or decreased risk of cancer at 13 anatomical sites (p ≤ 0.05), compared to blood group O. Consistent with assessment using a false discovery rate approach, significant associations with ABO blood group were observed for cancer of the pancreas, breast, and upper gastrointestinal tract (mouth, salivary glands, pharynx, esophageal adenocarcinoma and stomach). Discussion Our study reconfirms the association between ABO blood group and cancer risk and exact underlying mechanisms involved needs further research.
AB - Introduction The associations between ABO blood group and cancer risk have been studied repeatedly, but results have been variable. Consistent associations have only been reported for pancreatic and gastric cancers. Materials and methods We estimated associations between different ABO blood groups and site-specific cancer risk in a large cohort of healthy blood donors from Sweden and Denmark. Results A total of 1.6 million donors were followed over 27 million person-years (20 million in Sweden and 7 million in Denmark). We observed 119,584 cancer cases. Blood groups A, AB and B were associated either with increased or decreased risk of cancer at 13 anatomical sites (p ≤ 0.05), compared to blood group O. Consistent with assessment using a false discovery rate approach, significant associations with ABO blood group were observed for cancer of the pancreas, breast, and upper gastrointestinal tract (mouth, salivary glands, pharynx, esophageal adenocarcinoma and stomach). Discussion Our study reconfirms the association between ABO blood group and cancer risk and exact underlying mechanisms involved needs further research.
KW - ABO
KW - Blood groups
KW - Cancer
KW - False-discovery rate
UR - http://www.scopus.com/inward/record.url?scp=84978909210&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2016.06.005
DO - 10.1016/j.canep.2016.06.005
M3 - Article
C2 - 27459465
AN - SCOPUS:84978909210
SN - 1877-7821
VL - 44
SP - 40
EP - 43
JO - Cancer Epidemiology
JF - Cancer Epidemiology
ER -