A systematic review of peri-operative melatonin

L. P.H. Andersen*, M. U. Werner, J. Rosenberg, I. Gögenur

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I2 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

    OriginalsprogEngelsk
    Sider (fra-til)1163-1171
    Antal sider9
    TidsskriftAnaesthesia
    Vol/bind69
    Udgave nummer10
    DOI
    StatusUdgivet - 1 jan. 2014

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