TY - JOUR
T1 - A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
AU - Sørensen, Anders Lindholm
AU - Kallenbach, Klaus
AU - Hasselbalch, Hans Carl
PY - 2016/1/1
Y1 - 2016/1/1
N2 - We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.
AB - We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.
KW - Alendronate
KW - JAK2-V617F mutation
KW - Myeloproliferative neoplasms
KW - Polycythemia vera
KW - Simvastatin
UR - http://www.scopus.com/inward/record.url?scp=84978240373&partnerID=8YFLogxK
U2 - 10.1016/j.lrr.2016.06.004
DO - 10.1016/j.lrr.2016.06.004
M3 - Article
C2 - 27489765
AN - SCOPUS:84978240373
VL - 6
SP - 20
EP - 23
JO - Leukemia Research Reports
JF - Leukemia Research Reports
SN - 2213-0489
ER -