A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

Dirk Rades; Carlos A Narvaez; Laura Splettstößer; Claudia Dömer; Cornelia Setter; Christian Idel; Julika Ribbat-Idel; Sven Perner; Tobias Bartscht; Denise Olbrich; Steven E Schild; Jesper Carl

doi:10.1016/j.radonc.2019.07.023

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

Dirk Rades^*, Carlos A Narvaez, Laura Splettstößer, Claudia Dömer, Cornelia Setter, Christian Idel, Julika Ribbat-Idel, Sven Perner, Tobias Bartscht, Denise Olbrich, Steven E Schild, Jesper Carl

^*Corresponding author af dette arbejde

Klinisk Onkologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Mepitel� Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ?2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50?Gy, 65.2% vs. 59.3% at 60?Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

Originalsprog	Engelsk
Sider (fra-til)	79-82
Antal sider	4
Tidsskrift	Radiotherapy and Oncology
Vol/bind	139
DOI	https://doi.org/10.1016/j.radonc.2019.07.023
Status	Udgivet - okt. 2019

Bibliografisk note

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10.1016/j.radonc.2019.07.023

Citationsformater

Rades, D., Narvaez, C. A., Splettstößer, L., Dömer, C., Setter, C., Idel, C., Ribbat-Idel, J., Perner, S., Bartscht, T., Olbrich, D., Schild, S. E., & Carl, J. (2019). A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). Radiotherapy and Oncology, 139, 79-82. https://doi.org/10.1016/j.radonc.2019.07.023

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title = "A randomized trial (RAREST-01) comparing Mepitel{\textregistered} Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)",

abstract = "Mepitel� Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ?2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50?Gy, 65.2% vs. 59.3% at 60?Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).",

keywords = "Head-and-neck cancer, Radiation dermatitis, Randomized trial, Mepitel (R) Film, Standard care",

author = "Dirk Rades and Narvaez, {Carlos A} and Laura Splettst{\"o}{\ss}er and Claudia D{\"o}mer and Cornelia Setter and Christian Idel and Julika Ribbat-Idel and Sven Perner and Tobias Bartscht and Denise Olbrich and Schild, {Steven E} and Jesper Carl",

year = "2019",

month = oct,

doi = "10.1016/j.radonc.2019.07.023",

language = "English",

volume = "139",

pages = "79--82",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

}

Rades, D, Narvaez, CA, Splettstößer, L, Dömer, C, Setter, C, Idel, C, Ribbat-Idel, J, Perner, S, Bartscht, T, Olbrich, D, Schild, SE & Carl, J 2019, 'A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)', Radiotherapy and Oncology, bind 139, s. 79-82. https://doi.org/10.1016/j.radonc.2019.07.023

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). / Rades, Dirk; Narvaez, Carlos A; Splettstößer, Laura et al.

I: Radiotherapy and Oncology, Bind 139, 10.2019, s. 79-82.

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

TY - JOUR

T1 - A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

AU - Rades, Dirk

AU - Narvaez, Carlos A

AU - Splettstößer, Laura

AU - Dömer, Claudia

AU - Setter, Cornelia

AU - Idel, Christian

AU - Ribbat-Idel, Julika

AU - Perner, Sven

AU - Bartscht, Tobias

AU - Olbrich, Denise

AU - Schild, Steven E

AU - Carl, Jesper

PY - 2019/10

Y1 - 2019/10

N2 - Mepitel� Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ?2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50?Gy, 65.2% vs. 59.3% at 60?Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

AB - Mepitel� Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ?2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50?Gy, 65.2% vs. 59.3% at 60?Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).

KW - Head-and-neck cancer

KW - Radiation dermatitis

KW - Randomized trial

KW - Mepitel (R) Film

KW - Standard care

U2 - 10.1016/j.radonc.2019.07.023

DO - 10.1016/j.radonc.2019.07.023

M3 - Article

C2 - 31431372

SN - 0167-8140

VL - 139

SP - 79

EP - 82

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)

Abstract

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