A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population

Louise T. Dalgaard, Thorkild I.A. Sørensen, Thomas Drivsholm, Knut Borch-Johnsen, Teis Andersen, Torben Hansen, Oluf Pedersen

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstrakt

    Variability of the uncoupling protein 3 (UCP3) promoter has been associated with increased body mass index (BMI) and altered lipid profiles. Here we tested the hypothesis that variation of the UCP3 promoter is associated with either juvenile or maturity-onset obesity or body weight change over a 26-yr follow-up among Danish subjects. Mutation screening of approximately 1 kb 5′ upstream of the UCP3 gene revealed one previously described -55 C→T variant. The frequency of the polymorphism was evaluated by restriction fragment length polymorphism analysis in four groups of subjects: 1) a group of 744 obese Danish men who at the draft board examinations had a body mass index (BMI) of at least 31 kg/m2, 2) a randomly selected control group consisting of 857 draftees, 3) 258 middle-aged subjects, and 4) 409 60-yr-old subjects. The frequency of the T allele was 26.0% (95% confidence interval, 23.8-28.2%) among the obese draftees and 26.9% (24.8-29.0%) in the control group (P = 0.6). The variant was not associated with BMI at a young age or with weight gain after a 26-yr follow-up. The frequency of the T allele was 29.5% (25.6-33.4%) in the middle-aged group and 25.8% (22.8-28.8%) among the 60-yrold subjects. The polymorphism was not associated with increased BMI or percent body fat in these 2 groups. It is concluded that this variant does not play a major role in the development of common obesity among Danish subjects.

    OriginalsprogEngelsk
    Sider (fra-til)1398-1402
    Antal sider5
    TidsskriftJournal of Clinical Endocrinology and Metabolism
    Vol/bind86
    Udgave nummer3
    DOI
    StatusUdgivet - 30 apr. 2001

    Fingeraftryk Udforsk hvilke forskningsemner 'A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population' indeholder.

    Citationsformater