A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: A cross-sectional study

Jacob P. Thyssen, Allan Linneberg, Berit C. Carlsen, Jeanne D. Johansen, Kare Engkilde, Torben Hansen, Flemming Pociot, Oluf Pedersen, Michael Meldgaard, Pal B. Szecsi, Steen Stender, Torkil Menné

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    Abstrakt

    Background: Filaggrin proteins are located in the skin and prevent epidermal water loss and impede the entry of micro-organisms, allergens and chemicals. Filaggrin null mutations are strongly associated with ichthyosis vulgaris and atopic dermatitis. Objective: The authors aimed to investigate the association between filaggrin null mutations, atopic dermatitis and diabetes. Design: A random sample of 3335 adults from the general population in Denmark was filaggringenotyped for R501X and 2282del4 null-mutations and questioned about atopic dermatitis and diabetes. Furthermore, two independent study populations of patients with type 1 (n=104) or 2 (n=774) diabetes were genotyped. Results: In a crude data analysis, a positive association was detected between the filaggrin null genotype and, respectively, subjects from the general population who reported diabetes (p=0.04) and patients with established type 2 diabetes (p=0.073). Adjustment for age and gender resulted in significant associations for patients with type 2 diabetes (p=0.048) and subjects with self-reported diabetes (p=0.032). Conclusions: Adult Danes with a filaggrin null genotype had a significantly increased prevalence of self-reported diabetes. This finding was replicated when an independent sample of Danish patients with established type 2 diabetes was compared with control subjects from the general population.

    OriginalsprogEngelsk
    Artikelnummere000062
    TidsskriftBMJ open
    Vol/bind1
    Udgave nummer1
    DOI
    StatusUdgivet - 17 maj 2011

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