A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Andrés Ingason; Ina Giegling; Sven Cichon; Thomas Hansen; Henrik B. Rasmussen; Jimmi Nielsen; Gesche Jürgens; Pierandrea Muglia; Annette M. Hartmann; Eric Strengman; Catalina Vasilescu; Thomas W. Mühleisen; Srdjan Djurovic; Ingrid Melle; Bernard Lerer; Hans Jürgen Möller; Clyde Francks; Olli P.H. Pietiläinen; Jouko Lonnqvist; Jaana Suvisaari; Annamari Tuulio-Henriksson; Muriel Walshe; Evangelos Vassos; Marta di Forti; Robin Murray; Chiara Bonetto; Sarah Tosato; Rita M. Cantor; Marcella Rietschel; Nick Craddock; Michael J. Owen; Leena Peltonen; Ole A. Andreassen; Markus M. Nöthen; David St Clair; Roel A. Ophoff; Michael C. O'Donovan; David A. Collier; Thomas Werge; Dan Rujescu

doi:10.1093/hmg/ddq009

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Andrés Ingason^*, Ina Giegling, Sven Cichon, Thomas Hansen, Henrik B. Rasmussen, Jimmi Nielsen, Gesche Jürgens, Pierandrea Muglia, Annette M. Hartmann, Eric Strengman, Catalina Vasilescu, Thomas W. Mühleisen, Srdjan Djurovic, Ingrid Melle, Bernard Lerer, Hans Jürgen Möller, Clyde Francks, Olli P.H. Pietiläinen, Jouko Lonnqvist, Jaana SuvisaariAnnamari Tuulio-Henriksson, Muriel Walshe, Evangelos Vassos, Marta di Forti, Robin Murray, Chiara Bonetto, Sarah Tosato, Rita M. Cantor, Marcella Rietschel, Nick Craddock, Michael J. Owen, Leena Peltonen, Ole A. Andreassen, Markus M. Nöthen, David St Clair, Roel A. Ophoff, Michael C. O'Donovan, David A. Collier, Thomas Werge, Dan Rujescu

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10^-5-1.7 × 10^-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

Originalsprog	Engelsk
Artikelnummer	ddq009
Sider (fra-til)	1379-1386
Antal sider	8
Tidsskrift	Human Molecular Genetics
Vol/bind	19
Udgave nummer	7
DOI	https://doi.org/10.1093/hmg/ddq009
Status	Udgivet - 12 jan. 2010

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Citationsformater

Ingason, A., Giegling, I., Cichon, S., Hansen, T., Rasmussen, H. B., Nielsen, J., Jürgens, G., Muglia, P., Hartmann, A. M., Strengman, E., Vasilescu, C., Mühleisen, T. W., Djurovic, S., Melle, I., Lerer, B., Möller, H. J., Francks, C., Pietiläinen, O. P. H., Lonnqvist, J., ... Rujescu, D. (2010). A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Human Molecular Genetics, 19(7), 1379-1386. Artikel ddq009. https://doi.org/10.1093/hmg/ddq009

@article{dc53d59d6f43439b9317b059d7116dd5,

title = "A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia",

abstract = "The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.",

author = "Andr{\'e}s Ingason and Ina Giegling and Sven Cichon and Thomas Hansen and Rasmussen, {Henrik B.} and Jimmi Nielsen and Gesche J{\"u}rgens and Pierandrea Muglia and Hartmann, {Annette M.} and Eric Strengman and Catalina Vasilescu and M{\"u}hleisen, {Thomas W.} and Srdjan Djurovic and Ingrid Melle and Bernard Lerer and M{\"o}ller, {Hans J{\"u}rgen} and Clyde Francks and Pietil{\"a}inen, {Olli P.H.} and Jouko Lonnqvist and Jaana Suvisaari and Annamari Tuulio-Henriksson and Muriel Walshe and Evangelos Vassos and {di Forti}, Marta and Robin Murray and Chiara Bonetto and Sarah Tosato and Cantor, {Rita M.} and Marcella Rietschel and Nick Craddock and Owen, {Michael J.} and Leena Peltonen and Andreassen, {Ole A.} and N{\"o}then, {Markus M.} and {St Clair}, David and Ophoff, {Roel A.} and O'Donovan, {Michael C.} and Collier, {David A.} and Thomas Werge and Dan Rujescu",

year = "2010",

month = jan,

day = "12",

doi = "10.1093/hmg/ddq009",

language = "English",

volume = "19",

pages = "1379--1386",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "7",

}

Ingason, A, Giegling, I, Cichon, S, Hansen, T, Rasmussen, HB, Nielsen, J, Jürgens, G, Muglia, P, Hartmann, AM, Strengman, E, Vasilescu, C, Mühleisen, TW, Djurovic, S, Melle, I, Lerer, B, Möller, HJ, Francks, C, Pietiläinen, OPH, Lonnqvist, J, Suvisaari, J, Tuulio-Henriksson, A, Walshe, M, Vassos, E, di Forti, M, Murray, R, Bonetto, C, Tosato, S, Cantor, RM, Rietschel, M, Craddock, N, Owen, MJ, Peltonen, L, Andreassen, OA, Nöthen, MM, St Clair, D, Ophoff, RA, O'Donovan, MC, Collier, DA, Werge, T & Rujescu, D 2010, 'A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia', Human Molecular Genetics, bind 19, nr. 7, ddq009, s. 1379-1386. https://doi.org/10.1093/hmg/ddq009

TY - JOUR

T1 - A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

AU - Ingason, Andrés

AU - Giegling, Ina

AU - Cichon, Sven

AU - Hansen, Thomas

AU - Rasmussen, Henrik B.

AU - Nielsen, Jimmi

AU - Jürgens, Gesche

AU - Muglia, Pierandrea

AU - Hartmann, Annette M.

AU - Strengman, Eric

AU - Vasilescu, Catalina

AU - Mühleisen, Thomas W.

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Lerer, Bernard

AU - Möller, Hans Jürgen

AU - Francks, Clyde

AU - Pietiläinen, Olli P.H.

AU - Lonnqvist, Jouko

AU - Suvisaari, Jaana

AU - Tuulio-Henriksson, Annamari

AU - Walshe, Muriel

AU - Vassos, Evangelos

AU - di Forti, Marta

AU - Murray, Robin

AU - Bonetto, Chiara

AU - Tosato, Sarah

AU - Cantor, Rita M.

AU - Rietschel, Marcella

AU - Craddock, Nick

AU - Owen, Michael J.

AU - Peltonen, Leena

AU - Andreassen, Ole A.

AU - Nöthen, Markus M.

AU - St Clair, David

AU - Ophoff, Roel A.

AU - O'Donovan, Michael C.

AU - Collier, David A.

AU - Werge, Thomas

AU - Rujescu, Dan

PY - 2010/1/12

Y1 - 2010/1/12

N2 - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

AB - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=77952519163&partnerID=8YFLogxK

U2 - 10.1093/hmg/ddq009

DO - 10.1093/hmg/ddq009

M3 - Article

C2 - 20071346

AN - SCOPUS:77952519163

SN - 0964-6906

VL - 19

SP - 1379

EP - 1386

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 7

M1 - ddq009

ER -

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Abstract

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