A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Andrés Ingason, Ina Giegling, Sven Cichon, Thomas Hansen, Henrik B. Rasmussen, Jimmi Nielsen, Gesche Jürgens, Pierandrea Muglia, Annette M. Hartmann, Eric Strengman, Catalina Vasilescu, Thomas W. Mühleisen, Srdjan Djurovic, Ingrid Melle, Bernard Lerer, Hans Jürgen Möller, Clyde Francks, Olli P.H. Pietiläinen, Jouko Lonnqvist, Jaana SuvisaariAnnamari Tuulio-Henriksson, Muriel Walshe, Evangelos Vassos, Marta di Forti, Robin Murray, Chiara Bonetto, Sarah Tosato, Rita M. Cantor, Marcella Rietschel, Nick Craddock, Michael J. Owen, Leena Peltonen, Ole A. Andreassen, Markus M. Nöthen, David St Clair, Roel A. Ophoff, Michael C. O'Donovan, David A. Collier, Thomas Werge, Dan Rujescu

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    Abstrakt

    The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

    OriginalsprogEngelsk
    Artikelnummerddq009
    Sider (fra-til)1379-1386
    Antal sider8
    TidsskriftHuman Molecular Genetics
    Vol/bind19
    Udgave nummer7
    DOI
    StatusUdgivet - 12 jan. 2010

    Fingeraftryk Udforsk hvilke forskningsemner 'A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia' indeholder.

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